Table 4 A) Strongest positive features in first gait/tremor cohort B) Difference in PD progression odds ratio between deep learning prodromal cohorts (Fig. 1) and gait/tremor cohorts (Table 2)

Description

Gait/Tremor OR

Gait/Tremor Adjusted P Value

Percent of non-PD patients with history of feature

Percent of PD patients with history of feature

Bipolar disorder

3.392

1.04E-88

1.54

3.42

Major depressive disorder

1.628

1.44E-27

5.95

6.64

Voice disturbance

2.04

8.74E-21

2.10

4.15

Memory loss

1.725

5.39E-18

3.46

6.39

Other non-epithelial cancer of skin

1.334

4.14E-17

10.2

16.25

Senile cataract

1.233

1.75E-16

24.2

31.63

Other persistent mental disorders due to conditions classified elsewhere

1.944

1.33E-14

1.53

3.32

Actinic keratosis

1.219

1.06E-12

18.2

26.7

Urinary incontinence

1.414

1.16E-12

6.53

9.00

Depression

1.293

6.30E-12

13.8

14.78

Symptoms concerning nutrition, metabolism, and development

1.434

2.70E-10

4.78

7.25

Frequency of urination and polyuria

1.269

1.47E-09

10.9

15.4

Malaise and fatigue

1.133

5.64E-07

34.6

37.9

Seborrheic dermatitis

1.475

8.92E-07

2.92

4.58

Inflammation of eyelids

1.325

1.06E-06

5.86

7.90

Description

Prediagnostic OR

Prediagnostic Adjusted P value

Gait/Tremor OR

Gait/Tremor P Value

 Major depressive disorder

3.10

2.28E-103

1.63

1.43E-27

 Mood disorders

3.62

4.54E-18

1.77

1.50E-05

 Bipolar

5.68

1.82E-73

3.39

1.03E-88

 Depression

2.57

3.73E-109

1.29

6.29E-12

 Other anemias

1.13

0.412

0.74

2.67E-18

 Iron deficiency anemia secondary to blood loss (chronic)

1.61

3.48E-05

0.77

0.028

 Constipation

2.24

4.42E-72

1.17

0.001

 Frequency of urination and polyuria

1.66

4.96E-39

1.26

1.47E-09

 Urinary incontinence

2.11

2.56E-46

1.41

1.16E-12

 Hypersomnia

2.61

3.65E-12

1.43

0.010

 Hypotension NOS

1.97

3.53E-19

0.8

0.054

 Dizziness and giddiness

2.29

2.35E-133

1.08

0.025