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Table 1 Sociodemographic and clinical characteristics at baseline of patients exposed to Central Nervous System drugs

From: Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia

N, % Total N = 137,880 Cases N = 12,616 Controls N = 125,264 p-value
Mean age, SD 72.6, 13.2 72.9, 13.2 72.6, 13.2 0.009
Sex, female 60216, 43.7 5486, 43.5 54730, 43.7 0.658
N visits in PHC
Missing values 15165, 11.0 682, 5.4 14483, 11.6 <0.001
<5 27055, 22.0 1860, 15.6 25195, 22.7 <0.001
5-9 33155, 27.0 2460, 20.6 30695, 27.7  
10-24 46191, 37.6 4837, 40.5 41354, 37.3
≥25 16314, 13.3 2777, 23.3 13537, 12.2
Smoking status
Missing values 18895, 13.7 1294, 10.3 17601, 14.1 <0.001
Current smokers 16172, 13.6 2020, 17.8 14152, 13.1 <0.001
BMI mean, SD 28.9, 4.7 28.8, 4.9 28.9, 4.7 0.273
Missing values 78443, 56.9 6610, 52.4 71833, 57.3 <0.001
Obesity 21708, 36.5 2180, 36.3 19528, 36.5 <0.001
MEDEA     <0.001
U 8431, 6.1 1216, 9.6 7215, 5.8
R 25909, 18.8 2343, 18.6 23566, 18.8
U1-U3 58111, 42.1 4955, 39.3 53156, 42.4
U4-U5 45429, 32.9 4102, 32.5 41327, 33.0
GFR
Missing values 56401, 40.9 4186, 33.2 52215, 41.7 <0.001
<30 mL/min/1.73m2 1599, 2.0 311, 3.7 1288, 1.8 <0.001
30-44 5357, 6.6 802, 9.5 4555, 6.2  
45-59 12751, 15.6 1568, 18.6 11183, 15.3
≥60 61772, 75.8 5749, 68.2 56023, 76.7
Cardiovascular risk, high 14978, 10.9 2511, 19.9 12467, 10.0 <0.001
Comorbidities
Anxiety 12792, 9.3 1177, 9.3 11615, 9.3 0.836
Arthrosis 31921, 23.2 2823, 22.4 29098, 23.2 0.031
Cancer 24479, 17.8 2306, 18.3 22173, 17.7 0.106
COPD 16594, 12.0 1822, 14.4 14772, 11.8 <0.001
Dementia 6903, 5.0 828, 6.6 6075, 4.8 <0.001
Depression 7723, 5.6 853, 6.8 6870, 5.5 <0.001
Diabetes 29158, 21.1 3890, 30.8 25268, 20.2 <0.001
Dyslipidaemia 52057, 37.8 5007, 39.7 47050, 37.6 <0.001
Epilepsy 1050, 0.8 207, 1.6 843, 0.7 <0.001
Fibromyalgia 1266, 0.9 124, 1.0 1142, 0.9 <0.001
Hypertension 73250, 53.1 7626, 60.4 65624, 52.4 <0.001
Ischaemic heart disease 11401, 8.3 1745, 13.8 9656, 7.7 <0.001
Neuropathies 5067, 3.7 575, 4.6 4492, 3.6 <0.001
Peripheral artery disease 3888, 2.8 916, 7.3 2972, 2.4 <0.001
Ulcers 4274, 3.1 444, 3.5 3830, 3.1 0.005
  1. SD standard deviation, PHC primary healthcare, BMI body mass index, MEDEA socioeconomic index, (unknown urban area, U# urban areas), rural area, GFR glomerular filtration rate, COPD chronic obstructive pulmonary disease