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Table 2 Comedications at baseline of patients exposed to Nervous System drugs

From: Risk of ischaemic stroke associated with antiepileptic drugs: a population-based case-control study in Catalonia

N, % Total
N = 137,880
Cases
N = 12,616
Controls
N = 125,264
p-value
Acetic acid derivatives 58,208, 42.2 5652, 44.8 52,556, 42.0 < 0.001
Analgesics (metamizol and paracetamol) 109,801, 79.6 10,771, 85.4 99,030, 79.1 < 0.001
Anti-dementia agents 8907, 6.5 861, 6.8 8046, 6.4 0.080
Antidepressants 39,851, 28.9 4465, 35.4 35,386, 28.2 < 0.001
Antihypertensive agents 3774, 2.7 576, 4.6 3198, 2.6 < 0.001
Antithrombotic drugs 39,951, 29.0 8613, 68.3 31,338, 25.0 < 0.001
Antipsychotics 20,024, 14.5 2361, 18.7 17,663, 14.1 < 0.001
Anxiolytics 62,234, 45.1 6536, 51.8 55,698, 44.5 < 0.001
Beta-blockers 18,022, 13.1 2864, 22.7 15,158, 12.1 < 0.001
Blood glucose-lowering drugs 20,733, 15.0 2896, 23.0 17,837, 14.2 < 0.001
Calcium channel-blockers 18,013, 13.1 2448, 19.4 15,565, 12.4 < 0.001
Cardiac therapy 13,233, 9.6 2251, 17.8 10,982, 8.8 < 0.001
Coxibs and oxicams 22,471, 16.3 2020, 16.0 20,451, 16.3 0.369
Diuretics 28,656, 20.8 3794, 30.1 24,862, 19.8 < 0.001
Gastrointestinal tract 2505, 1.8 491, 3.9 2014, 1.6 < 0.001
Hypnotics and sedatives 23,208, 16.8 2607, 20.7 20,601, 16.4 < 0.001
Insulins 6072, 4.4 1276, 10.1 4796, 3.8 < 0.001
Lipid-modifying agents 42,897, 31.1 6119, 48.5 36,778, 29.4 < 0.001
Opioids (phentanil, buprenorphine and tramadol) 33,489, 24.3 3672, 29.1 29,817, 23.8 < 0.001
Propionic acid derivatives 93,012, 67.5 8839, 70.1 84,173, 67.2 < 0.001
Psychostimulants, ADHD-agents and nootropics 11,948, 8.7 1390, 11.0 10,558, 8.4 < 0.001
Renin-angiotensin agents 54,778, 39.7 6657, 52.8 48,121, 38.4 < 0.001
Other anti-inflammatories (glucosamine and chondroitin sulphate) 17,342, 12.6 1433, 11.4 15,909, 12.7 < 0.001
  1. ADHD attention deficit hyperactivity disorder