Table 2 Comedications at baseline of patients exposed to Nervous System drugs
N, % | Total N = 137,880 | Cases N = 12,616 | Controls N = 125,264 | p-value |
|---|---|---|---|---|
Acetic acid derivatives | 58,208, 42.2 | 5652, 44.8 | 52,556, 42.0 | < 0.001 |
Analgesics (metamizol and paracetamol) | 109,801, 79.6 | 10,771, 85.4 | 99,030, 79.1 | < 0.001 |
Anti-dementia agents | 8907, 6.5 | 861, 6.8 | 8046, 6.4 | 0.080 |
Antidepressants | 39,851, 28.9 | 4465, 35.4 | 35,386, 28.2 | < 0.001 |
Antihypertensive agents | 3774, 2.7 | 576, 4.6 | 3198, 2.6 | < 0.001 |
Antithrombotic drugs | 39,951, 29.0 | 8613, 68.3 | 31,338, 25.0 | < 0.001 |
Antipsychotics | 20,024, 14.5 | 2361, 18.7 | 17,663, 14.1 | < 0.001 |
Anxiolytics | 62,234, 45.1 | 6536, 51.8 | 55,698, 44.5 | < 0.001 |
Beta-blockers | 18,022, 13.1 | 2864, 22.7 | 15,158, 12.1 | < 0.001 |
Blood glucose-lowering drugs | 20,733, 15.0 | 2896, 23.0 | 17,837, 14.2 | < 0.001 |
Calcium channel-blockers | 18,013, 13.1 | 2448, 19.4 | 15,565, 12.4 | < 0.001 |
Cardiac therapy | 13,233, 9.6 | 2251, 17.8 | 10,982, 8.8 | < 0.001 |
Coxibs and oxicams | 22,471, 16.3 | 2020, 16.0 | 20,451, 16.3 | 0.369 |
Diuretics | 28,656, 20.8 | 3794, 30.1 | 24,862, 19.8 | < 0.001 |
Gastrointestinal tract | 2505, 1.8 | 491, 3.9 | 2014, 1.6 | < 0.001 |
Hypnotics and sedatives | 23,208, 16.8 | 2607, 20.7 | 20,601, 16.4 | < 0.001 |
Insulins | 6072, 4.4 | 1276, 10.1 | 4796, 3.8 | < 0.001 |
Lipid-modifying agents | 42,897, 31.1 | 6119, 48.5 | 36,778, 29.4 | < 0.001 |
Opioids (phentanil, buprenorphine and tramadol) | 33,489, 24.3 | 3672, 29.1 | 29,817, 23.8 | < 0.001 |
Propionic acid derivatives | 93,012, 67.5 | 8839, 70.1 | 84,173, 67.2 | < 0.001 |
Psychostimulants, ADHD-agents and nootropics | 11,948, 8.7 | 1390, 11.0 | 10,558, 8.4 | < 0.001 |
Renin-angiotensin agents | 54,778, 39.7 | 6657, 52.8 | 48,121, 38.4 | < 0.001 |
Other anti-inflammatories (glucosamine and chondroitin sulphate) | 17,342, 12.6 | 1433, 11.4 | 15,909, 12.7 | < 0.001 |