Table 1 Summary of previous reports on lacosamide-induced neutropenia
From: Lacosamide-induced sinus node dysfunction followed by severe agranulocytosis
Author (year) | Number of patients | Age, Sex | LCM dosage | LCM duration | Other AEDs | Adverse event | Clinical outcome (Days to remission) |
|---|---|---|---|---|---|---|---|
Husain et al. (2012)[4] | 2 | ND | ND | ND | ND | Neutropenia | ND |
Novy et al. (2013)[5] | 7(a) | ND | ND | ND | ND | Neutropenia or Rash (a) | ND |
Zadeh et al. (2015)[6] | 1 | 25, M | 400 mg/day | 46 days | LTG, LEV (Dose unknown) | Agranulocytosis | Improved (7 days after LCM was discontinued) |
Welsh et al. (2017)[7] | 6 | ND (children) | ND | ND | ND | Neutropenia | ND |
Rao et al. (2018)[8] | 1 | 20, M | 200 mg/day | 10 days | VPA 1000 mg/day, CLB 10 mg/day | Neutropenia | Improved (2 days after LCM was discontinued) |
Present case | 1 | 80, F | 200 mg/day | 9 days | LEV 2000 mg/day | Agranulocytosis | Death from sepsis |