Fig. 5

Topographical distribution of p62-positive intranuclear inclusions. Plotting scheme representing a topographical distribution of p62-positive intranuclear inclusions on sections at the level of the 4th lumbar cord (a), the primary motor cortex (b), and cerebellum at the level of the paravermis (c), dentate nucleus (d), and hemisphere (e). There is no eccentric distribution of p62-positive intranuclear inclusions to the areas with abundant large motor neurons, including the anterior horn of the spinal cord (a) and the deeper zone of the primary motor cortex (b). In the cerebellum, in contrast to the motor-related area with lack of eccentric distribution, the p62-positive intranuclear inclusions were predominantly distributed in the medial (paravermal) white matter (c)(d) rather than the lateral (hemispheric) white matter (e). DN: dentate nucleus, GM: gray matter, WM: white matter