Association between the HLA-B*1502 gene and mild maculopapular exanthema induced by antiepileptic drugs in Northwest China

Table 3 Comparison of AEDs types and HLA-B*1502 gene frequencies between AED-MPE¹ and AED-tolerant groups

	Drug2		Aromatic antiepileptic drugsHLA-B*1502 allele³		Gene frequency³(%)	P value²	P value³
	Aromatic	Non-Aromatic	+⁴	-⁴
AED-MPE	9	0	8	1	88.9	0.025*	0.045^*
AED-tolerant	88	68	42	46	47.7
Total	97	68	50	47	51.5

¹AED-MPE: antiepileptic drug-induced maculopapular exanthema
²AED-MPE compared with AED-tolerant group in different drug types: x² = 4.995
³ AED-MPE compared with AED-tolerant group in aromatic antiepileptic drugs HLA-B*1502 allele: x² = 4.013
⁴+: positive; −: negative
*P < 0.05(two-sided) was statistically significant

ISSN: 1471-2377