Impact of social and mobility restrictions in Parkinson’s disease during COVID-19 lockdown

BMC Neurology

Table 2 Comparison of results of each variable pre- and post-isolation period. Data are given as median values with 1st and 3rd quartiles (25- and 75-percentile, respectively Q1 and Q3)

	Pre-isolation Median (Q1; Q3)	Post-isolation Median (Q1; Q3)	Cohen d_z	Achieved Power^c	p-value^a,b
BMI (kg/m²)	26.5 (23.0; 29.6)	27.4 (23.2; 29.6)	0.703	0.841	0.031^bd
MDS-UPDRS Part III	14.5 (11.8; 21.3)	19 (12.8; 31.0)	0.513	0.651	0.092^a
Mini-BESTest	23 (21.0; 25.5)	19 (16.3; 21.0)	0.994	0.974	0.005^bd
6MWT (m)	565.5 (370.8; 660.6)	510.0 (405.0; 665.0)	0.027	0.201	0.799^b
NFOG-Q	6.0 (0.0; 13.8)	8.5 (0.0; 15.5)	0.353	0.454	0.313^a
MoCA (corrected score)	24.2 (21.7; 26.0)	24.5 (23.3; 26.0)	0.257	0.345	0.392^b
PD-CFRS	0.5 (0.0; 1.0)	1.0 (0.8; 1.0)	0.677	0.821	0.123^a
IADL	5 (5.0; 6.3)	5 (5.0; 6.3)
ADL	6.0 (6.0; 6.0)	6.0 (6.0; 6.0)
PDQ-39	30.5 (17.0; 45.3)	32.5 (20.0; 44.3)	0.215	0.304	0.472^b

Note. ^aWilcoxon signed-rank test or ^bt-test for continuous variable and McNemar test for discrete variable. MDS-UPDRS Part III = MDS-Unified Parkinson Disease Rating Scale - part III; Mini-BESTest = Mini-Balance Evaluation Systems Test. 6MWT = Six-minute walk test; NFOG-Q = New Freezing of Gait Questionnaire. MoCA = Montreal Cognitive Assessment scale; PD-CFRS = Parkinson’s disease cognitive functional rating scale; ADL = Activities of Daily Living questionnaire; IADL = Instrumental Activities of Daily Living questionnaire; BMI = Body Mass Index; PDQ-39 = Parkinson’s disease Quality of Life Questionnaire. ^cPost-hoc power analysis. Achieved power was calculated based on Cohen’s d_z and an α error probability of 0.2
^dSignificant isolation period effect (pre vs. post-isolation evaluation)

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