Table 3 Comparison of data at baseline between the preserved and reduced DMN connectivity groups
Variables | Preserved DMN connectivity group (n = 13) | Reduced DMN connectivity group (n = 7) | P value |
|---|---|---|---|
Age (years) | 80.0, 65–89 | 80.0, 69–85 | 0.877 |
Sex (women/men) | 5/8 | 3/4 | 0.848 |
Disease duration (years) | 2.7, 0.2–5.6 | 1.8, 0.1–5.1 | 0.211 |
Educational attainment (years) | 9.0, 8–18 | 9.0, 6–12 | 0.241 |
Responder/non-responder | 11/2 | 3/4 | 0.052 |
iNPHGS | |||
 Gait | 2.0, 1–3 | 2.0, 0–3 | 0.817 |
 Cognition | 2.0, 1–3 | 3.0, 2–3 | 0.046 |
 Urination | 1.0, 0–3 | 2.0, 0–3 | 0.536 |
 Total | 5.0, 2–8 | 7.0, 2–8 | 0.183 |
MMSE (/30) | 25.0, 13–29 | 23.0, 11–27 | 0.135 |
FAB (/18) | 13.0, 9–15 | 11.0, 5–16 | 0.275 |
RAVLT | |||
 Immediate recall (/75) | 25.0, 14–41 | 18.0, 6–24 | 0.008 |
 Delayed recall (/15) | 2.0, 0–9 | 0.0, 0–3 | 0.046 |
 Recognition (/30) | 27.0, 20–30 | 21.0, 14–25 | 0.003 |
TUG | |||
 Completion time (seconds) | 12.4, 7.2–53.7 | 16.9, 8.4–50.2 | 0.485 |
 Number of steps | 22.0, 14–81 | 21.0, 16–62 | 0.699 |
 DMN functional connectivity | 2.978, 2.512–3.570 | 2.297, 1.887–2.665 | < 0.001 |
 ROI FA | 0.449, 0.425–0.493 | 0.475, 0.436–0.488 | 0.056 |
 DMN/FA | 6.608, 5.860–7.454 | 4.791, 4.065–5.708 | < 0.001 |