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Table 5 Allele and genotype distribution of patients with response and not achieving seizure free to sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene

SNPs

Genotypes

Alleles

 

Response (n = 109)

Not seizure-free (n = 91)

 

Response A:B; not seizure-free A:B

Odds ratio (95% CI)

P*

A/B

AA

AB

BB

AA

AB

BB

p

SCN1A

rs121918808

C/T

108

1

0

90

1

0

1.0000

217:1; 181:1

0.834 (0.052–13.430)

1.0000

 

rs200176684

C/T

108

0

1

91

0

0

1.0000

216:2; 182:0

 

0.5028

 

rs201985242

G/C

109

0

0

90

1

0

0.7017

218:0; 181:1

 

0.4550

SCN1B

rs55742440

T/C

77

29

3

47

35

9

0.0097

183:35; 129:53

0.466 (0.287–0.754)

0.0016

 

rs3746255

C/T

104

4

1

85

6

0

0.5169

212:6; 176:6

0.830 (0.263–2.620)

0.7773

 

rs67486287

G/C

80

27

2

57

28

6

0.1140

187:31; 142:40

0.589 (0.351–0.987)

0.0431

 

rs67701503

C/A

80

27

2

57

28

6

0.1140

187:31; 142:40

0.589 (0.351–0.987)

0.0431

 

rs2305748

C/T

80

27

2

57

28

6

0.1140

187:31; 142:40

0.589 (0.351–0.987)

0.0431

 

rs369032304

G/A

109

0

0

90

1

0

0.4550

218:0; 181:1

 

0.4550

 

rs72558026

G/A

108

1

0

86

5

0

0.0941

217:1; 177:5

0.163 (0.019–1.409)

0.0965

SCN2A

rs2060198

T/A

103

5

1

87

3

1

0.8656

211:7; 177:5

1.174 (0.366–3.765)

0.7913

 

rs17183814

G/A

76

30

3

62

27

2

0.9169

182:36; 151:31

0.964 (0.569–1.631)

0.8875

 

rs138497939

A/C

107

2

0

91

0

0

0.5016

216:2; 182:0

 

0.5028

 

rs185590667

T/C

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

 

rs199925238

G/A

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

 

rs186154973

G/A

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

SCN9A

rs9646771

T/C

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

 

rs3750904

T/C

78

26

5

69

20

2

0.6430

182:36; 158:24

1.302 (0.745–2.277)

0.3537

 

rs199756028

G/A

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

 

rs200613417

A/T

109

0

0

90

1

0

0.4550

218:0; 181:1

 

0.4550

 

rs200956485

G/A

108

1

0

91

0

0

1.0000

217:1; 182:0

 

1.0000

  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction