Skip to main content

Table 5 Allele and genotype distribution of patients with response and not achieving seizure free to sodium channel blocking antiseizure medications

From: Response to Sodium Channel blocking Antiseizure medications and coding polymorphisms of Sodium Channel genes in Taiwanese epilepsy patients

Gene SNPs Genotypes Alleles
  Response (n = 109) Not seizure-free (n = 91)   Response A:B; not seizure-free A:B Odds ratio (95% CI) P*
A/B AA AB BB AA AB BB p
SCN1A rs121918808 C/T 108 1 0 90 1 0 1.0000 217:1; 181:1 0.834 (0.052–13.430) 1.0000
  rs200176684 C/T 108 0 1 91 0 0 1.0000 216:2; 182:0   0.5028
  rs201985242 G/C 109 0 0 90 1 0 0.7017 218:0; 181:1   0.4550
SCN1B rs55742440 T/C 77 29 3 47 35 9 0.0097 183:35; 129:53 0.466 (0.287–0.754) 0.0016
  rs3746255 C/T 104 4 1 85 6 0 0.5169 212:6; 176:6 0.830 (0.263–2.620) 0.7773
  rs67486287 G/C 80 27 2 57 28 6 0.1140 187:31; 142:40 0.589 (0.351–0.987) 0.0431
  rs67701503 C/A 80 27 2 57 28 6 0.1140 187:31; 142:40 0.589 (0.351–0.987) 0.0431
  rs2305748 C/T 80 27 2 57 28 6 0.1140 187:31; 142:40 0.589 (0.351–0.987) 0.0431
  rs369032304 G/A 109 0 0 90 1 0 0.4550 218:0; 181:1   0.4550
  rs72558026 G/A 108 1 0 86 5 0 0.0941 217:1; 177:5 0.163 (0.019–1.409) 0.0965
SCN2A rs2060198 T/A 103 5 1 87 3 1 0.8656 211:7; 177:5 1.174 (0.366–3.765) 0.7913
  rs17183814 G/A 76 30 3 62 27 2 0.9169 182:36; 151:31 0.964 (0.569–1.631) 0.8875
  rs138497939 A/C 107 2 0 91 0 0 0.5016 216:2; 182:0   0.5028
  rs185590667 T/C 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
  rs199925238 G/A 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
  rs186154973 G/A 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
SCN9A rs9646771 T/C 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
  rs3750904 T/C 78 26 5 69 20 2 0.6430 182:36; 158:24 1.302 (0.745–2.277) 0.3537
  rs199756028 G/A 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
  rs200613417 A/T 109 0 0 90 1 0 0.4550 218:0; 181:1   0.4550
  rs200956485 G/A 108 1 0 91 0 0 1.0000 217:1; 182:0   1.0000
  1. Abbreviations: CI confidence interval, SNP single nucleotide polymorphism
  2. * The significance level is set to be 0.0024 or less using Bonferroni correction