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Table 6 Effects of clinical parameters on the relationship between NLR and relapse

From: Association of neutrophil-to-lymphocyte ratio (NLR) with the prognosis of first attack neuromyelitis optica spectrum disorder (NMOSD): a retrospective cohort study

Variables

N

Relapse

OR (95% CI)

P value

P for interaction

Age, years

 < 60

261

1.25 (1.13–1.38)

< 0.001

0.107

 ≥60

63

1.64 (1.16–2.30)

0.0047

Sex

 Male

93

1.14 (1.01–1.28)

0.0339

0.021

 Female

231

1.43 (1.23–1.67)

< 0.001

Hypertension

 No

279

1.28 (1.15–1.42)

< 0.001

0.851

 Yes

45

1.24 (0.97–1.60)

0.0882

Initial EDSS

 < 5

140

1.27 (1.10–1.46)

< 0.001

0.912

 ≥5

184

1.25 (1.10–1.42)

< 0.001

Anti-AQP4 antibodies

 Negative

91

1.17 (1.03–1.33)

0.019

0.139

 Positive

180

1.36 (1.17–1.58)

< 0.001

LETM

 No

55

1.58 (1.11–2.23)

0.010

0.533

 Yes

165

1.40 (1.20–1.64)

< 0.001

Immunoglobulins

 No

291

1.29 (1.16–1.43)

< 0.001

0.908

 Yes

33

1.26 (0.94–1.69)

0.120

Immunosuppressants

 No

213

1.26(1.13–1.40)

< 0.001

0.516

 Yes

111

1.36 (1.10–1.68)

0.004

PLR

 < 134

173

2.27 (1.58–3.26)

< 0.001

< 0.001

 ≥134

151

1.15 (1.05–1.26)

0.004

LMR

 < 3.1

117

1.11 (1.01–1.23)

0.035

0.017

 ≥3.1

207

1.41 (1.18–1.70)

< 0.001

DMT

 NO

279

1.32 (1.18,1.48)

 

0.312

 YES

45

1.18(1.00,1.39)

 
  1. Diabetes and hormones are too different between the groups, and the interaction is negligible
  2. EDSS Extended disability status scale, LMR Lymphocyte-to-monocyte technical ratio, NLR Neutrophil-to-lymphocyte ratio, PLR Platelet-to-lymphocyte ratio, LETM longitudinally extensive transverse myelitis, AQP4 aquaporin-4, DMT disease-modifying treatment started during the follow-up
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BMC Neurology

ISSN: 1471-2377

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