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Table 2 Neuroimaging finding and plasma CYP450 metabolite levels on admission in patients with and without m-MCAI

From: 20-hydroxyeiscosatetraenoic acid may be as a predictor of malignant middle cerebral artery infarction in patients with massive middle cerebral artery infarction

Factor

Patients with m-MCAI

(n = 77)

Patients without m-MCAI

(n = 179)

P value

Early signs at the first CT scan (n, %)

69 (89.6)

141 (78.8)

0.045

 Hypodensity

59 (76.6)

139 (77.7)

0.863

 Mass effect

56 (72.7)

91 (50.8)

< 0.001

  Grade I

15 (19.5)

80 (44.7)

 

  Grade II

27 (35.1)

11 (6.1)

 

  Grade III

14 (18.2)

0 (0.0)

 

 ASPECTS

4 (3-6)

7 (6-10)

0.036

Infarct volume > 145 cm3 at second CT scan (n, %)

71 (92.2)

18 (10.1)

< 0.001

20-HETE at admission (pmol/L)

1924.6 ± 194.8

1698.7 ± 173.5

< 0.001

EETs at admission (nmol/l)

66.7 ± 17.6

70.4 ± 18.9

0.123

DiHETEs at admission (nmol/l)

80.2 ± 19.1

75.8 ± 17.6

0.089

  1. m-MCAI malignant middle cerebral artery infarction, CT computed tomography, ASPECTS Alberta Stroke Program Early CT Score, CYP450 cytochrome P450, HETE hydroxyeicosatetraenoic acid, DiHETEs dihydroxyeicosatrienoic acids, EET epoxyeicosatrienoic acids