Table 1 Participant Characteristics
Characteristic | Anemia | Non-Anemia | P value |
|---|---|---|---|
No. | 117 | 529 | – |
Age (years, mean ± SD) | 66.04 ± 10.99 | 61.14 ± 10.03 | < 0.01 |
Female (n, %) | 56, 47.9% | 208, 39.3% | 0.21 |
APOE ε4 carriers (n, %) | 7, 6.0% | 96, 18.1% | < 0.01 |
Education years (years, mean ± SD) | 9.25 ± 4.22 | 9.77 ± 4.41 | 0.25 |
CM-MMSE (mean ± SD) | 27.34 ± 2.31 | 27.95 ± 2.07 | < 0.01 |
Coronary heart disease (n, %) | 18, 15.38% | 83,12.84% | 0.36 |
History of stroke (n, %) | 7, 5.98% | 16, 2.47% | < 0.01 |
Hypertension (n, %) | 49, 41.88% | 246, 38.08% | 0.35 |
Diabetes mellitus (n, %) | 24,20.68% | 94,14.66% | 0.04 |
Glomerular filtration rate, mL/min | 83.93 ± 22.60 | 91.60 ± 15.12 | < 0.01 |
Dyslipidemia (n, %) | 3, 2.56% | 24,3.71% | 0.46 |
CSF biomarkers | |||
Aβ42 (pg/ml, mean ± SD) | 145.03 ± 58.07 | 157.39 ± 70.32 | 0.19 |
Aβ40 (pg/ml, mean ± SD) | 6231.48 ± 2410.13 | 6116 ± 2572.62 | 0.40 |
t-tau (pg/ml, mean ± SD) | 179.76 ± 87.07 | 158.12 ± 67.15 | 0.32 |
p-tau (pg/ml, mean ± SD) | 36.82 ± 8.13 | 37.18 ± 8.55 | 0.70 |
T-tau/Aβ42 ratio (mean ± SD) | 1.36 ± 0.80 | 1.19 ± 0.61 | 0.01 |
P-tau/Aβ42 ratio (mean ± SD) | 0.27 ± 0.09 | 0.26 ± 0.09 | 0.10 |
Aβ42/ Aβ40 ratio (mean ± SD) | 0.02 ± 0.01 | 0.03 ± 0.24 | 0.04 |