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Table 1 Participant Characteristics

From: Anaemia and cerebrospinal fluid biomarkers of Alzheimer’s pathology in cognitively normal elders: the CABLE study

Characteristic Anemia Non-Anemia P value
No. 117 529
Age (years, mean ± SD) 66.04 ± 10.99 61.14 ± 10.03 < 0.01
Female (n, %) 56, 47.9% 208, 39.3% 0.21
APOE ε4 carriers (n, %) 7, 6.0% 96, 18.1% < 0.01
Education years (years, mean ± SD) 9.25 ± 4.22 9.77 ± 4.41 0.25
CM-MMSE (mean ± SD) 27.34 ± 2.31 27.95 ± 2.07 < 0.01
Coronary heart disease (n, %) 18, 15.38% 83,12.84% 0.36
History of stroke (n, %) 7, 5.98% 16, 2.47% < 0.01
Hypertension (n, %) 49, 41.88% 246, 38.08% 0.35
Diabetes mellitus (n, %) 24,20.68% 94,14.66% 0.04
Glomerular filtration rate, mL/min 83.93 ± 22.60 91.60 ± 15.12 < 0.01
Dyslipidemia (n, %) 3, 2.56% 24,3.71% 0.46
CSF biomarkers
 Aβ42 (pg/ml, mean ± SD) 145.03 ± 58.07 157.39 ± 70.32 0.19
 Aβ40 (pg/ml, mean ± SD) 6231.48 ± 2410.13 6116 ± 2572.62 0.40
 t-tau (pg/ml, mean ± SD) 179.76 ± 87.07 158.12 ± 67.15 0.32
 p-tau (pg/ml, mean ± SD) 36.82 ± 8.13 37.18 ± 8.55 0.70
 T-tau/Aβ42 ratio (mean ± SD) 1.36 ± 0.80 1.19 ± 0.61 0.01
 P-tau/Aβ42 ratio (mean ± SD) 0.27 ± 0.09 0.26 ± 0.09 0.10
 Aβ42/ Aβ40 ratio (mean ± SD) 0.02 ± 0.01 0.03 ± 0.24 0.04
  1. Abbreviations: CSF Cerebrospinal fluid, CM-MMSE China-Modified Mini-Mental State Examination, β-Amyloid, t-tau Total tau, p-tau Phosphorylated tau, HGB Hemoglobin, SD Standard Deviation