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Table 2 Subgroup Analysis in proportion of relapse free patients

From: Safety and efficacy of interleukin-6-receptor inhibitors in the treatment of neuromyelitis optica spectrum disorders: a meta-analysis

Subgroups (no. of studies)

 Study type

Effect size (95% C.I.)

I2

Subgroup difference

 Observational Study (6)

68.6% (95% CI: 0.44–0.94), p < 0.001

82.69%

0.19

 Randomized Controlled Trial (1)

86.4% (95% CI: 0.78–0.95), p < 0.001

NA

Duration of follow-up

  < 20 months (3)

73.9% (95% CI:0.49–0.98), p < 0.001

53.54%

0.94

  > 20 months (3)

70.8% (95% CI:0.33–1.09), p < 0.001

89.55%

Percentage of AQP-4 positivity

 All (100%) (4)

64.6% (95% CI:0.27–1.02), p = 0.001

86.32%

0.31

 Not All (100%) (3)

84.3% (95% CI: 0.76–0.92), p < 0.001

0%

Site of Injection

 Intravenous (5)

67.1% (95% CI:0.45–0.89), p < 0.001

64.68%

p = 0.001

 Subcutaneous (1)

100% (95% CI:0.98–1.02), p < 0.001

NA

 Mixed (1)

66.7% (95% CI:0.40–0.93), p < 0.001

NA