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Table 2 Association between WBC counts and the risk of fatal stroke in the GBCS, 2003–2017 (n = 27,811)

From: Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study

 

Quartiles of WBC (*10^9/L)

P value trend

Quartiles of NEUT (*10^9/L)

P value trend

Quartiles of LYM (*10^9/L)

P value trend

1st (< 5.3)

2nd 5.3–6.1)

3rd (6.2–7.2)

4th(> 7.2)

1st(< 3.0)

2nd (3.0–3.6)

3rd (3.7–4.4)

4th (> 4.5)

1st(< 1.8)

2nd(1.8–2.1)

3rd(2.2–2.5)

4th (> 2.5)

All stroke

 Person years

80,325

80,555

82,196

77,783

 

79,448

83,038

77,517

80,857

 

86,199

93,678

73,358

67,624

 

 per 10^5 person-years

110.8

121.7

165.5

231.4

 

109.5

116.8

152.2

248.6

 

178.7

156.9

140.4

146.4

 

 No. of deaths

89

98

136

180

 

87

97

118

201

 

154

147

103

99

 

 Model 1 (HR; 95% CI)

Ref.

1.09 (0.82–1.45)

1.48 (1.13–1.93)b

2.08 (1.61–2.68)c

< 0.001

Ref.

1.06 (0.79–1.41)

1.38 (1.05–1.82)a

2.25 (1.75–2.90)c

< 0.001

Ref.

0.88 (0.70–1.10)

0.78 (0.61–1.00)

0.82 (0.64–1.06)

0.07

 P value

 

0.58

0.004

< 0.001

  

0.70

0.02

< 0.001

  

0.26

0.05

0.13

 

 Model 2 (HR; 95% CI)

Ref.

0.96 (0.72–1.28)

1.24 (0.94–1.64)

1.53 (1.16–2.02)b,

< 0.001

Ref.

0.87 (0.65–1.17)

1.06 (0.80–1.41)

1.45 (1.10–1.89)b

0.001

Ref.

1.01 (0.80–1.27)

0.92 (0.71–1.19)

0.95 (0.73–1.24)

0.56

 P value

 

0.76

0.13

0.003

  

0.36

0.68

0.008

 

.

0.92

0.51

0.71

 

Ischaemic stroke

 Person years

79,914

80,070

81,618

77,012

 

79,045

82,625

76,875

80,068

 

85,536

93,017

72,896

67,163

 

 per 10^5 person-years

52.6

48.7

80.9

103.9

 

46.8

54.5

61.1

122.4

 

86.5

77.4

52.1

64.0

 

 No. of deaths

42

39

66

80

 

37

45

47

98

 

74

72

38

43

 

 Model 1 (HR; 95% CI)

Ref.

0.92 (0.59–1.42)

1.52 (1.03–2.24)a

1.97 (1.36–2.86)c

< 0.001

Ref.

1.16 (0.75–1.78)

1.29 (0.84–1.99)

2.59 (1.78–3.79)c

< 0.001

Ref.

0.90 (0.65–1.24)

0.60 (0.41–0.89)a

0.75 (0.51–1.09)

0.03

P value

 

0.69

0.03

< 0.001

  

0.52

0.24

< 0.001

  

0.51

0.01

0.13

 

 Model 2 (HR; 95% CI)

Ref.

0.82 (0.53–1.28)

1.30 (0.87–1.94)

1.45 (0.96–2.18)

0.01

Ref.

0.95 (0.61–1.48)

1.00 (0.64–1.55)

1.65 (1.10–2.47)a

0.004

Ref.

1.05 (0.75–1.45)

0.71 (0.48–1.07)

0.89 (0.60–1.32)

0.24

 P value

 

0.38

0.21

0.08

  

0.83

0.99

0.02

  

0.80

0.10

0.56

 

Haemorrhagic stroke

 Person years

79,804

80,032

81,289

76,797

 

79,017

82,461

76,779

79,663

 

85,280

92,716

72,823

67,083

 

per 10^5 person-years

40.1

46.2

51.7

82.0

 

50.6

37.6

48.2

82.8

 

64.5

43.1

57.7

52.2

 

 No. of deaths

32

37

42

63

 

40

31

37

66

 

55

40

42

35

 

 Model 1 (HR; 95% CI)

Ref.

1.14 (0.71–1.83)

1.27 (0.80–2.01)

2.02 (1.32–3.10)b

0.001

Ref.

0.74 (0.46–1.18)

0.94 (0.60–1.47)

1.61 (1.09–2.39)a

0.004

Ref.

0.67 (0.45–1.01)

0.89 (0.60–1.33)

0.81 (0.53–1.24)

0.55

 P value

 

0.59

0.31

0.001

  

0.20

0.79

0.02

  

0.05

0.57

0.34

 

 Model 2 (HR; 95% CI)

Ref.

1.05 (0.65–1.70)

1.15 (0.71–1.85)

1.67 (1.05–2.67)a

0.02

Ref.

0.63 (0.39–1.02)

0.77 (0.49–1.22)

1.14 (0.74–1.75)

0.26

Ref.

0.77 (0.51–1.16)

1.03 (0.68–1.57)

0.94 (0.60–1.46)

0.94

 P value

 

0.84

0.57

0.03

  

0.06

0.27

0.56

  

0.21

0.88

0.77

 
  1. Ref: reference; C P < 0.001, b P < 0.01, aP < 0.05; model 1: a crude hazard ratio model without adjustment for confounders; model 2: a multivariate model adjusted for sex, age, education, occupation, diabetes, hypertension, dyslipidaemia, smoking, alcohol consumption, physical activity, body mass index, self-rated health, cancer, genitourinary disease (including nephropathy, prostatic disease, and gynaecologic diseases), chest disease (including chronic obstructive pulmonary disease, chronic bronchitis, emphysema, asthma, tuberculosis, and pneumonia) and platelet count
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BMC Neurology

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