Higher total white blood cell and neutrophil counts are associated with an increased risk of fatal stroke occurrence: the Guangzhou biobank cohort study

Table 4 Association between hs-CRP and the risk of fatal stroke in the GBCS, 2003–2017 (n = 11,601)

Quartiles of WBC (*10^9/L)	All stroke					Ischaemic stroke					Haemorrhagic stroke
Quartiles of WBC (*10^9/L)	1st (< 5.3)	2nd 5.3–6.1)	3rd (6.2–7.2)	4th (> 7.2)	P- value trend	1st (< 5.3)	2nd 5.3–6.1)	3rd (6.2–7.2)	4th (> 7.2)	P-value trend	1st (< 5.3)	2nd 5.3–6.1)	3rd (6.2–7.2)	4th (> 7.2)	P value trend
*Overall*
Person years	34,882	36,186	35,976	35,665		34,608	35,832	35,644	35,269		34,485	35,765	35,499	35,123
per 10^5 person-years	177.8	187.9	186.2	243.9		86.7	89.3	84.2	110.6		58.0	69.9	56.3	82.6
No. of deaths	62	68	67	87		30	32	30	39		20	25	20	29
Model 1 (HR; 95% CI)	Ref.	1.02 (0.72–1.44)	0.99 (0.70–1.40)	1.31 (0.94–1.81)	0.12	Ref.	0.98 (0.60–1.62)	0.90 (0.55–1.50)	1.19 (0.74–1.92)	0.53	Ref.	1.17 (0.65–2.11)	0.93 (0.50–1.73)	1.38 (0.78–2.44)	0.40
P value		0.92	0.96	0.11			0.95	0.70	0.48			0.60	0.82	0.27
Model 2 (HR; 95% CI)	Ref.	0.93 (0.66–1.32)	0.85 (0.61–1.21)	1.04 (0.74–1.47)	0.87	Ref.	0.90 (0.54–1.48)	0.78 (0.47–1.31)	0.92 (0.56–1.53)	0.70	Ref.	1.07 (0.59–1.93)	0.81 (0.43–1.52)	1.16 (0.64–2.11)	0.80
P value		0.69	0.38	0.81			0.66	0.36	0.76			0.84	0.51	0.62

Ref: reference; ^C P < 0.001, ^b P < 0.01, ^aP < 0.05; model 1: a crude hazard ratio model without adjustment for confounders; model 2: a multivariate model adjusted for sex, age, education, occupation, diabetes, hypertension, dyslipidaemia, smoking, alcohol consumption, physical activity, body mass index, self-rated health, cancer, genitourinary disease (including nephropathy, prostatic disease, and gynaecologic diseases), chest disease (including chronic obstructive pulmonary disease, chronic bronchitis, emphysema, asthma, tuberculosis, and pneumonia) and platelet count

ISSN: 1471-2377