Table 1 Characteristics of selected SNPs for core gut microbiota

OTU10032 unclassifed Enterobacteriaceae Species-level OTU

rs1009634

12

4,779,313

4,900,344

G

A

7.12E-09

−1.3

0.23

0.93

AKAP3

NDUFA9, GALNT8, RP11-234B24.2

0.0183

Bacilli class

rs10928827

2

129,426,740

129,473,850

G

A

1.02E-08

−0.2

0.04

0.19

HS6ST1

–

0.0180

Lactobacillales order

rs10928827

2

129,426,740

129,473,850

G

A

4.19E-09

−0.2

0.04

0.19

HS6ST2

–

0.0189

Unclassifed Erysipelotrichaceae

rs11626933

14

90,681,816

90,810,659

G

A

1.83E-08

−0.2

0.04

0.55

C14orf102

C14orf102

0.0173

Marinilabiliaceae family

rs11724031

4

77,441,448

77,467,405

G

A

2.44E−10

−1

0.15

0.68

SHROOM3

SHROOM3

0.0219

Unclassifed Marinilabiliaceae

rs11724031

4

77,441,448

77,467,405

G

A

2.44E-10

-1

0.15

0.68

SHROOM3

SHROOM3

0.0219

Erysipelotrichaceae family

rs11877825

18

10,566,345

10,595,758

G

T

2.82E-11

−0.3

0.04

0.34

NAPG

–

0.0242

Erysipelotrichia class

rs11877825

18

10,566,345

10,595,758

G

T

2.82E-11

−0.3

0.04

0.34

NAPG

–

0.0242

Erysipelotrichales order

rs11877825

18

10,566,345

10,595,758

G

T

2.82E-11

−0.3

0.04

0.34

NAPG

–

0.0242

Marinilabiliaceae family

rs11915634

3

1,452,602

1,517,331

T

C

2.99E-10

−1.3

0.21

0.14

CNTN6

–

0.0217

Unclassifed Marinilabiliaceae

rs11915634

3

1,452,602

1,517,331

T

C

2.99E-10

−1.3

0.21

0.14

CNTN7

–

0.0217

OTU10032 unclassifed Enterobacteriaceae

rs12149695

16

27,205,994

27,293,886

A

T

1.82E-09

0.61

0.10

0.23

FLJ21408

NSMCE1, FLJ21408, KDM8

0.0198

OTU15355 Dialister Species-level OTU

rs12442649

15

37,968,393

38,035,538

G

A

3.72E-08

−1.5

0.27

0.85

TMCO5A

–

0.0166

EscherichiaShigella

rs13096731

3

58,014,818

58,089,851

A

G

2.55E-08

−0.4

0.08

0.12

FLNB

FLNB

0.0170

OTU10032 unclassifed Enterobacteriaceae

rs13276516

8

56,589,428

56,596,140

A

G

5.54E-09

− 0.6

0.10

0.41

TGS1

–

0.0186

Lactobacillales order

rs1362404

16

51,955,443

52,017,380

T

G

1.56E-08

0.23

0.04

7.50E-05

TOX3

–

0.0175

Bacilli class

rs148330122

19

38,497,288

38,631,252

C

T

1.32E-09

−0.5

0.08

0.18

SIPA1L3

SIPA1L3

0.0201

OTU10032 unclassifed Enterobacteriaceae

rs17085775

9

71,165,704

71,167,878

C

T

2.06E-08

−1

0.18

0.54

C9orf71

–

0.0172

Erysipelotrichaceae family

rs17421787

4

131,293,675

131,512,291

C

G

3.60E-08

−0.3

0.05

0.16

RP11-22 J15.1

–

0.0166

Erysipelotrichales order

rs17421787

4

131,293,675

131,512,291

C

G

3.60E-08

−0.3

0.05

0.16

RP11-22 J15.2

–

0.0166

Erysipelotrichia class

rs17421787

4

131,293,675

131,512,291

C

G

3.60E-08

−0.3

0.05

0.16

RP11-22 J15.3

–

0.0166

Unclassifed Acidaminococcaceae

rs17661843

7

48,381,902

48,433,594

T

C

3.72E-14

−1.4

0.18

0.26

ABCA13

ABCA13

0.0312

Bacilli class

rs2071199

20

43,030,809

43,037,422

T

C

1.24E-08

−0.3

0.06

0.58

HNF4A–AS1

HNF4A

0.0178

OTU10032 unclassifed Enterobacteriaceae Species-level OTU

rs2318350

8

139,889,972

139,942,500

T

C

3.65E-09

−1.2

0.19

0.95

COL22A1

COL22A1

0.0190

OTU10032 unclassifed Enterobacteriaceae

rs249733

5

141,877,862

141,911,748

T

C

4.74E-10

−0.7

0.10

0.68

SPRY4

–

0.0212

Actinobacteria class

rs34613612

21

32,184,901

32,204,347

C

G

6.34E-10

0.25

0.04

9.87E-03

KRTAP8–1

KRTAP8–1

0.0209

Actinobacteria phylum

rs34613612

21

32,184,901

32,204,347

C

G

6.34E-10

0.25

0.04

9.87E-03

KRTAP8–1

KRTAP8–1

0.0209

Enterobacteriaceae family

rs35275482

15

60,027,987

60,128,040

C

A

3.72E-11

−0.5

0.08

0.06

BNIP2

–

0.0239

Enterobacteriales order

rs35275482

15

60,027,987

60,128,040

C

A

3.72E-11

−0.5

0.08

0.06

BNIP3

–

0.0239

OTU10032 unclassifed Enterobacteriaceae Species-level OTU

rs3925158

3

38,161,078

38,313,688

C

G

6.29E-09

−1

0.17

0.78

SLC22A13

SLC22A13, MYD88, DLEC1, ACAA1, OXSR1

0.0185

Gammaproteobacteria class

rs4621152

2

217,857,450

217,924,261

C

T

1.40E-08

−0.3

0.05

0.79

AC007557.1

–

0.0176

Blautia genus

rs4669413

2

9,801,744

9,818,596

T

C

1.20E-08

−0.2

0.03

0.75

RP11–521D12.1

–

0.0178

Bacilli class

rs479105

12

3,357,596

3,393,503

T

C

1.21E-08

−0.2

0.04

0.48

PRMT8

–

0.0178

Unclassifed Acidaminococcaceae

rs56006724

2

228,486,044

228,523,585

A

G

6.35E-10

−0.9

0.14

0.93

C2orf83

C2orf83

0.0209

Lactobacillales order

rs59042687

3

95,359,287

95,823,523

T

G

6.22E-09

−0.2

0.04

0.02

LINC00879

–

0.0185

OTU13305 Fecalibacterium Species-level OTU

rs597205

1

112,379,026

112,415,622

T

C

7.68E-09

−0.6

0.11

0.85

C1orf183

C1orf183

0.0183

Lactobacillales order

rs62295801

3

162,444,724

163,236,170

G

T

5.32E-10

−0.3

0.04

0.21

LINC01192

LINC01192

0.0211

Lactobacillales order

rs7083345

10

7,020,329

7,044,987

T

C

2.89E-09

0.24

0.04

0.02

RP11-554I8.2

–

0.0199

Bacilli class

rs7083345

10

7,020,329

7,044,987

T

C

3.38E-10

0.25

0.04

0.02

RP11-554I8.2

–

0.0209

Lactobacillales order

rs7113056

11

122,091,502

122,154,110

C

T

1.72E-13

−0.5

0.07

0.07

RP11-166D19.1

–

0.0296

Unclassifed Acidaminococcaceae

rs75036654

1

37,717,219

37,780,821

C

T

4.94E-10

−1.4

0.22

0.06

LINC01137

–

0.0212

Bacilli class

rs7646786

3

185,729,634

185,742,372

T

C

2.29E-08

−0.2

0.04

0.5

LOC344887

–

0.0171

Unclassifed Porphyromonadaceae

rs7656342

4

9,721,358

9,895,176

A

G

2.80E-09

0.39

0.07

0.22

DRD5

SLC2A9, DRD5

0.0193

Blautia genus

rs79387448

2

103,099,953

103,239,356

C

T

7.68E-11

−0.3

0.05

0.66

SLC9A2

SLC9A2

0.0231

Unclassifed Porphyromonadaceae

rs9291879

5

66,515,817

66,550,855

C

T

3.51E-09

−0.6

0.10

0.08

CD180

–

0.0191

Gammaproteobacteria class

rs9300430

13

98,269,478

98,306,405

C

T

1.30E-09

−0.6

0.10

0.12

RAP2A

–

0.0201

Proteobacteria phylum

rs9323326

14

58,476,448

58,532,709

A

G

8.76E-10

−0.2

0.03

0.02

SLC35F4

C14orf37

0.0206

Unclassifed Enterobacteriaceae

rs938295

1

16,087,164

16,124,985

C

T

2.34E-08

−0.5

0.09

0.76

FBLIM1

FBLIM1

0.0171

Unclassifed Marinilabiliaceae

rs9831278

3

98,879,786

98,942,990

C

T

2.53E-08

−1.2

0.21

0.49

LINC00973

–

0.0170

Marinilabiliaceae family

rs9831278

3

98,879,786

98,942,990

C

T

2.53E-08

−1.2

0.21

0.49

LINC00974

–

0.0170

Unclassifed Acidaminococcaceae

rs986417

14

60,787,269

61,122,040

C

T

2.63E-09

−1.4

0.23

0.47

SIX6

SIX6, C14orf39, SIX1

0.0194

Marinilabiliaceae family

rs9996716

4

77,441,448

77,467,405

G

A

5.58E-09

−0.7

0.12

0.2

SHROOM3

SHROOM3

0.0186

Unclassifed Marinila-biliaceae

rs9996716

4

77,441,448

77,467,405

G

A

5.58E-09

−0.7

0.12

0.2

SHROOM3

SHROOM3

0.0186