Predictors for symptomatic intracranial hemorrhage after intravenous thrombolysis with acute ischemic stroke within 6 h in northern China: a multicenter, retrospective study

Table 4 Association of risk factors load with symptomatic intracranial hemorrhage (sICH)

No. of risk factors ^a	No. of subjects	No. of sICH cases	Odds ratio (95% confidence interval)
No. of risk factors ^a			Model 1^b	Model 2^c
Continuous variable (range 0–3)	1293	33	4.29 (2.73–6.74) ^‡	3.76 (2.19–6.44) ^‡
Categorical variable
0	435	1	1.00 (Reference)	1.00 (Reference)
1	511	4	3.42 (0.38–30.74)	2.28 (0.25–20.74)
2	272	19	28.98 (3.83–219.06) ^†	15.37 (1.96–120.90) ^†
3	58	9	69.28 (8.49–565.39) ^‡	29.05 (3.13–270.11) ^†
P for trend			< 0.001	< 0.001

^aThree risk factors were aggregated including NIHSS on admission higher than 10, DNT >50 min, and white blood cell ≥9000/mm³
^bModel 1: Unadjusted
^cModel 2: Adjusted for coronary heart disease, neutrophils ratio, and stroke subtype
^†P < 0.05
^‡P < 0.001

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