|
Characteristics
|
No.(%)of any COVID-19 cases
|
Odds Ratio
|
No.(%)of Inpatient COVID-19
|
Odds Ratio
|
No.(%)of COVID-19 related death
|
Odds Ratio
|
|---|
|
Exposed
|
Unexposed
|
(95% CI)
|
Exposed
|
Unexposed
|
(95% CI)
|
Exposed
|
Unexposed
|
(95% CI)
|
|---|
|
Sex
|
|
Female
|
347/1230 (28.2)
|
9082/50369 (18.0)
|
2.81 (2.46–3.21)
|
164/1230 (13.3)
|
2519/50369 (5.0)
|
2.46 (2.06–2.93)
|
76/1230 (6.2)
|
355/50369 (0.7)
|
4.27 (3.26–5.59)
|
|
Male
|
371/1387 (26.7)
|
8138/43289 (18.8)
|
2.20 (1.94–2.50)
|
215/1387 (15.5)
|
2851/43289 (6.6)
|
1.99 (1.70–2.33)
|
119/1387 (8.6)
|
631/43289 (1.5)
|
3.37 (2.72–4.17)
|
|
Age, years
|
|
≤ 66
|
50/187 (26.7)
|
8736/30254 (28.9)
|
1.05 (0.76–1.47)
|
28/187 (15.0)
|
1776/30254 (5.9)
|
2.06 (1.36–3.14)
|
7/187 (3.7)
|
87/30254 (0.3)
|
4.01 (1.63–9.89)
|
|
67–75
|
95/436 (21.8)
|
4046/26367 (15.3)
|
1.44 (1.14–1.82)
|
47/436 (10.8)
|
1287/26367 (4.9)
|
1.59 (1.15–2.19)
|
20/436 (4.6)
|
219/26367 (0.8)
|
3.13 (1.91–5.15)
|
|
≥ 76
|
573/1994 (28.7)
|
4438/37037 (12.0)
|
2.73 (2.46–3.03)
|
304/1994 (15.2)
|
2307/37037 (6.2)
|
2.25 (1.97–2.57)
|
168/1994 (8.4)
|
680/37037 (1.8)
|
4.03 (3.36–4.83)
|
|
BMI, kg/m2
|
|
< 24.9
|
182/696 (26.1)
|
4424/27367 (16.2)
|
3.09 (2.58–3.71)
|
91/696 (13.1)
|
1029/27367 (3.8)
|
3.14 (2.47–3.99)
|
52/696 (7.5)
|
130/27367 (0.5)
|
7.41 (5.21–10.54)
|
|
25.0–29.9
|
317/1082 (29.3)
|
7203/39782 (18.1)
|
2.85 (2.48–3.27)
|
161/1082 (14.9)
|
2155/39782 (5.4)
|
2.46 (2.06–2.95)
|
90/1082 (8.3)
|
372/39782 (0.9)
|
4.91 (3.82–6.31)
|
|
≥ 30
|
208/797 (26.1)
|
5447/25885 (21.0)
|
1.77 (1.50–2.09)
|
120/797 (15.1)
|
2120/25885 (8.2)
|
1.57 (1.28–1.93)
|
50/797 (6.3)
|
462/25885 (1.8)
|
1.88 (1.37–2.57)
|
|
Smoking
|
|
Never
|
325/1287 (25.3)
|
9076/48823 (18.6)
|
2.43 (2.12–2.78)
|
162/1287 (12.6)
|
2460/48823 (5.0)
|
2.33 (1.95–2.78)
|
79/1287 (6.1)
|
358/48823 (0.7)
|
4.05 (3.11–5.27)
|
|
Ever
|
381/1296 (29.4)
|
8033/44200 (18.2)
|
2.51 (2.21–2.85)
|
211/1296 (16.3)
|
2857/44200 (6.5)
|
2.09 (1.78–2.45)
|
115/1296 (8.9)
|
613/44200 (1.4)
|
3.57 (2.87–4.44)
|
|
Alcohol use
|
|
Never
|
48/176 (27.3)
|
1072/4420 (24.3)
|
1.75 (1.22–2.51)
|
30/176 (17.0)
|
381/4420 (8.6)
|
1.81 (1.18–2.78)
|
6/176 (3.4)
|
79/4420 (1.8)
|
0.99 (0.41–2.36)
|
|
Previous
|
63/182 (34.6)
|
693/3534 (19.6)
|
2.34 (1.68–3.24)
|
41/182 (22.5)
|
315/3534 (8.9)
|
2.13 (1.45–3.14)
|
20/182 (11.0)
|
72/3534 (2.0)
|
3.58 (2.05–6.24)
|
|
Current
|
602/2237 (26.9)
|
15,385/85364 (18.0)
|
2.55 (2.31–2.82)
|
305/2237 (13.6)
|
4643/85364 (5.4)
|
2.23 (1.96–2.54)
|
168/2237 (7.5)
|
824/85364 (1.0)
|
4.15 (3.47–4.98)
|
|
Annual household income, £
|
|
< 18,000
|
279/909 (30.7)
|
3501/18534 (18.9)
|
2.44 (2.10–2.84)
|
158/909 (17.4)
|
1490/18534 (8.0)
|
2.11 (1.75–2.54)
|
75/909 (8.3)
|
368/18534 (2.0)
|
3.05 (2.33–3.99)
|
|
18,000-51,999
|
197/846 (23.3)
|
7597/40269 (18.9)
|
2.28 (1.93–2.70)
|
94/846 (11.1)
|
2120/40269 (5.3)
|
2.21 (1.77–2.77)
|
52/846 (6.1)
|
335/40269 (0.8)
|
4.44 (3.25–6.07)
|
|
> 52,000
|
45/218 (20.6)
|
3560/20178 (17.6)
|
2.13 (1.52–3.00)
|
15/218 (6.9)
|
761/20178 (3.8)
|
1.84 (1.07–3.16)
|
15/218 (6.9)
|
81/20178 (0.4)
|
8.61 (4.69–15.78)
|
|
Educational attainment
|
|
University degree
|
115/544 (21.1)
|
4307/28109 (15.3)
|
2.38 (1.92–2.96)
|
66/544 (12.1)
|
1170/28109 (4.2)
|
2.76 (2.10–3.64)
|
32/544 (5.9)
|
186/28109 (0.7)
|
4.70 (3.14–7.04)
|
|
Without University degree
|
290/1106 (26.2)
|
9310/46981 (19.8)
|
2.45 (2.13–2.83)
|
139/1106 (12.6)
|
2639/46981 (5.6)
|
2.21 (1.83–2.67)
|
81/1106 (7.3)
|
413/46981 (0.9)
|
4.59 (3.55–5.95)
|
|
Charlson Comorbidity Index
|
|
0
|
184/678 (27.1)
|
10,422/51302 (20.3)
|
2.59 (2.17–3.09)
|
80/678 (11.8)
|
2264/51302 (4.4)
|
3.17 (2.49–4.05)
|
46/678 (6.8)
|
238/51302 (0.5)
|
8.21 (5.82–11.57)
|
|
1
|
122/485 (25.2)
|
2760/15181 (18.2)
|
2.21 (1.78–2.75)
|
59/485 (12.2)
|
933/15181 (6.1)
|
2.22 (1.67–2.96)
|
31/485 (6.4)
|
157/15181 (1.0)
|
4.81 (3.18–7.28)
|
|
≥ 2
|
412/1454 (28.3)
|
4038/27175 (14.9)
|
2.33 (2.06–2.64)
|
240/1454 (16.5)
|
2173/27175 (8.0)
|
1.90 (1.64–2.21)
|
118/1454 (8.1)
|
591/27175 (2.2)
|
2.85 (2.30–3.52)
|
|
Calendar period
|
|
Before April 26th 2020
|
162/258 (62.8)
|
1218/2353 (51.8)
|
1.49 (1.13–1.97)
|
106/258 (41.1)
|
1030/2353 (43.8)
|
0.77 (0.59–1.02)
|
87/258 (33.7)
|
295/2353 (12.5)
|
2.19 (1.61–2.97)
|
|
April 27th 2020 to July 6th 2020
|
101/427 (23.7)
|
630/7456 (8.4)
|
4.00 (3.11–5.15)
|
47/427 (11.0)
|
325/7456 (4.4)
|
2.42 (1.73–3.39)
|
20/427 (4.7)
|
58/7456 (0.8)
|
4.02 (2.33–6.93)
|
|
July 7th 2020 to Dec 16th 2020
|
226/1040 (21.7)
|
7060/35252 (20.0)
|
1.72 (1.47–2.01)
|
117/1040 (11.2)
|
1874/35252 (5.3)
|
1.85 (1.50–2.27)
|
41/1040 (3.9)
|
277/35252 (0.8)
|
2.46 (1.74–3.49)
|
|
Dec 17th 2020 onward
|
229/892 (25.7)
|
8312/48597 (17.1)
|
2.52 (2.15–2.96)
|
109/892 (12.2)
|
2141/48597 (4.4)
|
2.27 (1.83–2.82)
|
47/892 (5.3)
|
356/48597 (0.7)
|
3.42 (2.47–4.75)
|
- Odds Ratio (95%) were derived from logistic regression models, which were adjusted for birth year, sex, race/ethnicity, body mass index, smoking, alcohol use, Townsend deprivation index, annual household income, educational attainment, and Charlson Comorbidity Index
