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Table 1 Patients with neuromyelitis optica spectrum disorder presenting with arrhythmia

From: Sick sinus syndrome as the initial manifestation of neuromyelitis optica spectrum disorder: a case report

Author, year (ref)

Age (years), sex

Type of arrhythmia

Other symptoms

MRI lesion

Treatment

Outcome

Tsouris et al., 2020 [6]

42, M

Sinus pauses

Hiccups, reduced visual acuity of the left eye, retrobulbar pain

Lower medulla oblongata, left optic nerve

PMI, IVMP and oral PSL

Complete recovery

Endo et al., 2020 [5]

22, F

Sinus arrest

Nausea, vertigo, nystagmus, diplopia, dysarthria, paresthesia of the left limbs

Dorsal part of the medulla oblongata

Temporary PM, IVMP and oral PSL

Improved

Komaki et al., 2020 [4]

77, M

Sinus arrest

Hiccups, vomiting

Area postrema

Temporary PM and oral PSL

Improved

Okada et al., 2012 [7]

78, M

Cardiorespiratory arrest

Hiccups, nausea, orthostatic hypotension, dysarthria, dysphagia

Medulla oblongata, cervical cord

IVMP, acyclovir, IVIg

Partially improved

Bigi et al., 2012 [8]

16, M

Sinus bradycardia

Hiccups, vomiting

Area postrema

IVMP

Complete recovery

Our patient

77, F

Sinus pauses

Nausea, vomiting, weakness of extremities, sensory impairment of the lower extremities

Dorsal part of the medulla oblongata, cervical cord

PMI, IVMP, PE and oral PSL

Partially improved

  1. IVMP intravenous methylprednisolone, PE plasma exchange, PMI pacemaker implantation, PSL prednisolone