Table 2 Univariable predictive clinic factors for early progression in neuromyelitis optica (negative binomial regression)

  Sex

    Male

1.61

0.30 – 8.63

0.578

    Female

Reference

–

–

  Skin color

    Black

0.757

0.16 – 3.58

0.726

    Others

Reference

–

–

  Age at onset (years)

1.07

1.01 – 1.12

0.020

  Co-morbidities

    Autoimmune disease

3.37

0.45 – 25.50

0.239

    Hypertension

0.90

0.20 – 4.16

0.896

    Diabetes mellitus

0.40

0.05 – 3.16

0.383

    Dyslipidemia

0.09

0.18 – 0.51

0.006

    Depression

0.20

0.04 – 1.12

0.067

    Smoking

0.56

0.06 – 4.90

0.597

  First syndrome

    Optic neuritis

0.06

0.01 – 0.44

0.006

    Area postrema

0.38

0.02 – 6.28

0.497

    Optic neuritis + transverse myelitis

0.10

0.01 – 0.66

0.017

    Others

0.94

0.30 – 2.92

0.917

    Transverse myelitis

Reference

–

–

  AQP4-IgG + 

1.26

0.24–6.59

0.781

  Number of brain injuries on MRI

1.13

0.66–1.92

0.657

  Topography of brain lesions on MRI

    Midbrain

1.07

0.00–5.97

0.276

    Pons

2.10

0.24–18.08

0.500

    Medulla Oblongata

2.45

0.37–16.04

0.349

    High cervical spinal cord

2.94

0.39–22.35

0.298

    Cerebellum

0.82

0.10–6.69

0.852

    Periventricular

4.35

0.69–27.66

0.119

    Area Postrema

6.55

0.98–43.58

0.052

  Optic nerve MRI lesions

0.13

0.00–8.71

0.346

  Delay until diagnosis (> 12 m)

12.53

3.12–50.26

 < 0.001