Fig. 3
From: Amyloid-β related angiitis presenting as eosinophilic meningitis: a case report
Pathological Studies. Brain biopsy demonstrating morphologic and immunohistochemical features of amyloid-β related angiitis (ABRA). Hematoxylin and eosin-stained sections revealed marked thickening of the leptomeningeal and cortical blood vessel walls by a homogenous eosinophilic material (A) which was positive for amyloid-β by immunohistochemistry (B). Scattered blood vessels also showed perivascular granulomatous inflammation with multinucleated giant cells (C) and transmural lymphoplasmacytic inflammation with fibrinoid necrosis of the blood vessel wall (D). Images were taken using an Olympus BX51 microscope equipped with 10× (0.30 NA) and 40× (0.75 NA) objectives and a Zeiss AxioCam HRc camera using ZEN 3.0 software with a resolution of 1.4 and 0.34 μm/pixel for panels A–B and C–D, respectively. Any adjustments were applied to the entire image. Threshold manipulation, expansion or contraction of signal ranges, and altering of high signals were not performed. Scale bars are 100 μm (A and B) and 20 μm (C and D)