Changes of biochemical biomarkers in the serum of children with convulsion status epilepticus: a prospective study

Table 2 Changes of serum biochemical biomarkers in children with CSE at different phases

Group	N	NSE (μg/l)	S-100B (μg/l)	CRP (mg/l)	VEGF (ng/l)	GFAP (ng/l)
Control median	30	6.138 ± 1.941 6.395	0.387 ± 0.040 0.395	3.915 ± 2.064 4.055	119.210 ± 31.681 117.66	2.471 ± 1.272 2.28
1 day median	57	20.553 ± 5.360^** 21.198	0.738 ± 0.391^** 0.583	11.128 ± 12.066^* 7.15	153.504 ± 31.246^** 153.28	2.826 ± 1.124 2.68
4 day median	57	10.094 ± 3.426^**## 10.433	0.468 ± 0.180^## 0.398	3.608 ± 2.261^## 3.310	138.536 ± 25.221^* 136.53	3.998 ± 1.211^**## 3.562
10 day median	57	6.90 ± 1.961^##&& 6.845	0.361 ± 0.073^##&& 0.375	3.568 ± 2.607^## 3.000	120.646 ± 44.21^##& 109.43	2.916 ± 0.777^&& 2.844

^*P < 0.05, **P < 0.01 vs. the control group; #P < 0.05, ##P < 0.01 vs. the 1 day group; &P < 0.05, &&P < 0.01 vs. the 4 day group. NSE neuron-specific enolase, VEGF vascular endothelial growth factor, S-100B S-100 calcium binding protein B, CRP C-reactive protein, GFAP glial fibrillary acidic protein

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