Predicting the onset of freezing of gait in Parkinson’s disease

BMC Neurology

Table 4 Univariate analysis of CSF biomarkers and genetic pattern at baseline for FoG onset during the 5-year follow up

Index	OR	95% CI		P
CSF biomarkers
Abeta	1.00	1.00	1.00	0.027*
Tau	1.00	0.99	1.00	0.622
pTau	1.00	0.94	1.06	0.885
aSyn	1.00	1.00	1.00	0.653
Genetic Pattern
APOE	0.94	0.64	1.40	0.775
APOE Genotype—number of e4 alleles	0.87	0.48	1.60	0.663
SNCA_rs3910105	1.35	0.86	2.12	0.194
SNCA_rs356181	0.96	0.63	1.44	0.826
MAPT	0.96	0.57	1.61	0.865

In the regression analysis, different genetic features were represented as numbers as below:
APOE: e2/e4 ~ 1, e3/e2 ~ 2, e3/e3 ~ 3, e4/e3 ~ 4, e4/e4 ~ 5, e2/e2 ~ 6
SNCA_rs356181: C/C ~ 1, C/T ~ 2, T/T ~ 3
SNCA_rs3910105: C/C ~ 1, C/T ~ 2, T/T ~ 3
MAPT: H1/H1 ~ 1, H1/H2 ~ 2, H2/H2 ~ 3
P <0.05 was presented with ‘*’

ISSN: 1471-2377