Table 5 Trend of the headache days by the location of the most intense pain
From: OnabotulinumtoxinA in chronic migraine: is the response dose dependent?
Number of the headache days | Number of the severe headache days | |
|---|---|---|
Frontal (n = 73) | ||
Baseline | 26.11 ± 5.23 | 15.42 ± 8.15 |
36 weeks before the increase | 14.51 ± 11.09 | 5.90 ± 6.74 |
24 weeks before the increase | 14.01 ± 11.27 | 5.11 ± 6.15 |
12 weeks before the increase | 13.08 ± 11.47 | 5.83 ± 7.44 |
Day of increase to 200 units | 13.19 ± 11.33 | 5.84 ± 7.31 |
12 weeks after the increase | 12.05 ± 11.15 | 4.68 ± 6.33 * |
24 weeks after the increase | 13.41 ± 11.11 | 4.57 ± 6.44 |
36 weeks after the increase | 11.37 ± 11.25 * | 4.08 ± 5.77 ** |
Temporoparietal (n = 51) | ||
Baseline | 26.16 ± 5.63 | 15.37 ± 7.80 |
36 weeks before the increase | 14.06 ± 10.85 | 5.25 ± 5.69 |
24 weeks before the increase | 12.35 ± 10.28 | 5.20 ± 5.44 |
12 weeks before the increase | 12.45 ± 9.62 | 5.08 ± 5.04 |
Day of increase to 200 units | 14.16 ± 10.43 | 6.00 ± 5.16 |
12 weeks after the increase | 11.86 ± 9.78 * | 4.18 ± 4.59 * |
24 weeks after the increase | 11.02 ± 10.24 ** | 2.98 ± 3.66 *** |
36 weeks after the increase | 11.14 ± 9.77 * | 4.02 ± 4.10 * |
Occipitonuchal (n = 28) | ||
Baseline | 23.50 ± 6.75 | 13.39 ± 6.62 |
36 weeks before the increase | 10.75 ± 9.59 | 3.93 ± 4.33 |
24 weeks before the increase | 12.86 ± 11.13 | 5.36 ± 7.36 |
12 weeks before the increase | 12.53 ± 10.24 | 3.82 ± 5.77 |
Day of increase to 200 units | 11.57 ± 9.55 | 4.36 ± 6.59 |
12 weeks after the increase | 8.61 ± 9.15 | 3.07 ± 3.94 |
24 weeks after the increase | 9.78 ± 9.65 | 2.61 ± 2.38 |
36 weeks after the increase | 7.39 ± 9.01 | 2.79 ± 3.33 |
Holocephalic (n = 23) | ||
Baseline | 27.22 ± 5.71 | 16.35 ± 9.26 |
36 weeks before the increase | 17.87 ± 10.54 | 9.56 ± 10.04 |
24 weeks before the increase | 15.83 ± 11.10 | 7.30 ± 8.45 |
12 weeks before the increase | 16.74 ± 10.73 | 6.04 ± 6.95 |
Day of increase to 200 units | 16.26 ± 11.30 | 7.65 ± 7.92 |
12 weeks after the increase | 15.35 ± 11.26 | 5.09 ± 3.89 |
24 weeks after the increase | 15.30 ± 11.03 | 4.83 ± 3.93 |
36 weeks after the increase | 14.04 ± 11.53 | 5.26 ± 4.97 |
Occipitonuchal and holocephalic (n = 51) | ||
Baseline | 25.18 ± 6.51 | 14.72 ± 7.98 |
36 weeks before the increase | 13.96 ± 10.55 | 6.47 ± 7.91 |
24 weeks before the increase | 14.20 ± 11.10 | 6.23 ± 7.85 |
12 weeks before the increase | 14.43 ± 10.57 | 4.82 ± 6.36 |
Day of increase to 200 units | 13.69 ± 10.54 | 5.84 ± 7.34 |
12 weeks after the increase | 11.65 ± 10.61 | 3.98 ± 4.01 |
24 weeks after the increase | 12.27 ± 10.56 | 3.61 ± 3.33 * |
36 weeks after the increase | 10.39 ± 10.66 * | 3.90 ± 4.29 * |