Table 1 Demographics and baseline characteristics between lower and higher tHcy groups

Number

113

114

Sex, male

61 (54.0%)

72 (63.2%)

0.161

Age, years

66.90 ± 8.69

67.30 ± 10.04

0.751

Body Mass Index, kg/m²

23.42 (22.22, 24.87)

23.52 (22.37, 25.95)

0.189

Hypertension

107 (94.7%)

100 (87.7%)

0.064

SBP, mmHg

152.04 ± 20.45

152.32 ± 20.23

0.920

DBP, mmHg

85.08 ± 10.31

83.74 ± 10.97

0.343

Diabetes

75 (66.4%)

69 (60.5%)

0.361

FPG, mmol/L

6.17 (5.29, 8.66)

5.98 (5.31, 8.81)

0.724

HbA1c, %

6.90 (6.00, 8.85)

6.55 (5.90, 8.90)

0.564

TIA history

24 (21.2%)

27 (23.7%)

0.659

Coronary heart disease

5 (4.4%)

10 (8.8%)

0.187

Current smoking

33 (29.2%)

50 (43.9%)

0.022*

Alcohol use

18 (15.9%)

19 (16.7%)

0.880

Hyperlipidemia

40 (35.7%)

36 (31.6%)

0.511

Total cholesterol, mmol/L

4.39 ± 1.15

4.40 ± 0.89

0.972

Triglyceride, mmol/L

1.48 (1.07, 2.28)

1.57 (1.13, 2.00)

0.995

HDL-C, mmol/L

1.04 (0.88, 1.24)

1.01 (0.85, 1.19)

0.251

LDL-C, mmol/L

2.42 ± 0.85

2.50 ± 0.68

0.453

Hemoglobin, g/L

137.00 (127.50, 149.00)

139.50 (129.75, 147.25)

0.508

Fibrinogen, g/L

2.96 (2.49, 3.41)

2.85 (2.38, 3.44)

0.472

CCrE, mL/(min*1.73m²)

88.87 (71.30, 101.51)

80.48 (63.06, 101.52)

0.116

Uric acid, μmol/L

284.00 (234.45, 337.25)

308.10 (262.78, 374.00)

0.013*

NIHSS at baseline

3 (2, 5)

3 (2, 5)

0.790

NIHSS at discharge

3 (2, 5)

3 (2, 5)

0.823

IPI classification

0.129

 PPI

76 (67.3%)

87 (76.3%)

 SDPI

37 (32.7%)

27 (23.7%)

Moderate to severe WMH

48 (42.5%)

43 (37.7%)

0.464

Lacunes

61 (54.0%)

66 (57.9%)

0.553

CSO-EPVS grade

0.261

0

5 (4.4%)

1 (0.9%)

1

52 (46.0%)

46 (40.4%)

2

36 (31.9%)

38 (33.3%)

3

13 (11.5%)

22 (19.3%)

4

7 (6.2%)

7 (6.1%)

Moderate to severe

CSO-EPVS

56 (49.6%)

67 (58.7%)

0.164

0

1 (0.9%)

0 (0.0%)

<0.001*

1

82 (72.6%)

52 (45.6%)

2

25 (22.1%)

37 (32.5%)

3

4 (3.5%)

24 (21.0%)

4

1 (0.9%)

1 (0.9%)

BG-EPVS

30 (26.5%)

62 (54.4%)

<0.001*

Brainstem-EPVS

24 (21.2%)

67 (58.8%)

<0.001*