Fig. 2

Serial changes in total amyotrophic lateral sclerosis Functional Rating Scale (ALSFRS)-R score during edaravone treatment in 16 patients. Based on the time point from ALS diagnosis, the first mark indicates ALSFRS-R score at the baseline of edaravone treatment; the second mark indicates the score at 24 weeks; the third mark indicates the score at 48 weeks; and the fourth mark indicates the score at 72 weeks. The circle indicates an evaluation that was conducted for 72 weeks, the diamond indicates 48 weeks, the triangle indicates 24 weeks, and the X mark indicates the patient died