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Table 3 The characteristics of patients after 2 weeks follow-up

From: Amphotericin B plus fluorocytosine combined with voriconazole for the treatment of non-HIV and non-transplant-associated cryptococcal meningitis: a retrospective study

Variables

Group I (n = 49)

Group II(n = 71)

Group III(n = 28)

P-value

BMRC stage (n, %)

 < 0.001

 1

16(32.7%)

7(9.9%)

0(0%)

 2

32(65.3%)

60(84.5%)

27(96.4%)

 3

1(2.0%)

4(5.6%)

1(3.6%)

Number of lumbar punctures within 2 weeks, median (IQR)

3(3–4)

3(2–4)

3(2–4)

0.431

CSF opening pressure, median (IQR), mmH2O

177.5(123.75–220)

210(160–265)

257(220–327.5)

 < 0.001

CSF cryptococci, median (IQR), count/ml

0(0–400)

85(0–1500)

72(1–333)

0.061

CSF clearance

 Case (n, %)

26(53.1%)

18(25.4%)

7(25.0%)

0.004*

CSF white blood cell, median (IQR), *10^6/l

70(32–120)

81(28–124)

80(30–123.25)

0.946

CSF protein, median (IQR), g/l

0.955(0.482–2.088)

0.97(0.56–1.80)

0.81(0.4925–1.3325)

0.414

CSF glucose, median (IQR), g/l

2.205(1.015–3.58)

1.83(0.89–2.46)

1.86(1.42–2.215)

0.072

CSF chloride, median (IQR), mmol/l

121.85(115.15–124.60)

118.9(114.2–122.6)

120.05(113.325–124.6)

0.276

  1. Group I: AMB + 5-FC + VOR, Group II: AMB + 5-FC + FLU, Group III: AMB + 5-FC. Data were presented as the median (IQR). Continuous variables were analyzed by one-way ANOVA or Kruskal–Wallis H test. Categorical variables were analyzed by Chi-square test or Fisher’s exact test
  2. *P < 0.05