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Table 3 Hazard ratio (95% CI) of mortality in patients with glioma (Based on histological stratification)

From: Exploring the relationship between age and prognosis in glioma: rethinking current age stratification

 

Diffuse astrocytoma

Anaplastic astrocytoma

Glioblastoma

Oligodendroglioma

Age

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

Four groups of age

 Birth to 19 years

1 (reference)

 

1 (reference)

 

1 (reference)

 

1 (reference)

 

 20-39 years

2.47 (2.08 to 2.95)

<0.001

0.46 (0.40 to 0.53)

<0.001

0.76 (0.68 to 0.84)

<0.001

3.03 (2.05 to 4.48)

<0.001

 40-64 years

5.74 (4.85 to 6.79)

<0.001

1.07 (0.94 to 1.22)

0.319

1.47 (1.34 to 1.60)

<0.001

5.21 (3.55 to 7.65)

<0.001

 65-84 years

16.34 (13.76 to 19.40)

<0.001

3.04 (2.66 to 3.48)

<0.001

2.85 (2.61 to 3.12)

<0.001

16.98 (11.40 to 25.29)

<0.001

Per 10 years of age

 0-9 years

1.05 (0.77 to 1.44)

0.751

1.36 (1.07 to 1.72)

0.012

1.04 (0.87 to 1.24)

0.682

1.30 (0.58 to 2.89)

0.521

 10-19 years

1 (reference)

 

1 (reference)

 

1 (reference)

 

1 (reference)

 

 20-29 years

2.31 (1.80 to 2.98)

<0.001

0.47 (0.38 to 0.57)

<0.001

0.67 (0.58 to 0.77)

<0.001

2.99 (1.82 to 4.90)

<0.001

 30-39 years

2.79 (2.18 to 3.57)

<0.001

0.55 (0.46 to 0.67)

<0.001

0.82 (0.72 to 0.93)

0.002

3.48 (2.16 to 5.61)

<0.001

 40-49 years

3.62 (2.84 to 4.63)

<0.001

0.75 (0.63 to 0.91)

0.003

1.19 (1.06 to 1.34)

0.003

4.39 (2.73 to 7.05)

<0.001

 50-59 years

7.59 (5.97 to 9.63)

<0.001

1.53 (1.28 to 1.83)

<0.001

1.50 (1.34 to 1.68)

<0.001

6.65 (4.13 to 10.70)

<0.001

 60-69 years

11.25 (8.86 to 14.28)

<0.001

2.32 (1.94 to 2.78)

<0.001

2.00 (1.79 to 2.25)

<0.001

11.58 (7.15 to 18.75)

<0.001

 70-79 years

19.66 (15.46 to 25.00)

<0.001

3.96 (3.30 to 4.76)

<0.001

3.16 (2.82 to 3.54)

<0.001

23.11 (14.07 to 37.98)

<0.001

 80-84 years

28.65 (21.93 to 37.42)

<0.001

6.61 (5.34 to 8.18)

<0.001

5.19 (4.62 to 5.83)

<0.001

46.44 (26.56 to 81.19)

<0.001

  1. HR Hazard ratio, CI Confidence interval. Adjusted for year (2000-2006,2007-2012 or 2013-2018), location (infratentorial, supratentorial or overlapping lesion), race (black, white or other) and gender (female or male)