Fig. 2
Results of analyses showing estimated odds ratios for the association between (for each cytokine) exposure and the risk of CRPS. Intra-assay coefficients of variation (CV) are provided for each cytokine. (a) primary analysis using the CRPS Budapest criteria, where exposure is defined as being above the 80th centile for controls; (b) secondary analysis treating log10 cytokine levels as continuous; (c) secondary analysis using the CRPS IASP criteria, where exposure is defined as being above the 80th centile for controls, adjusted for age (years), gender (male, female), and days since injury. Error bars represent the limits of the 95% confidence interval for the odds ratio. IL-8 = interleukin-8; IL-4 = interleukin-4; MIG = monokine induced by interferon-gamma; IL-2r = interleukin-2 receptor; IP-10 = interferon gamma-induced protein-10; IL-7 = interleukin-7; IL-2 = interleukin-2; IL-1Ra = interleukin 1 receptor antagonist; TNF-α = tumor necrosis factor alpha; IFN-γ = interferon gamma; IL-5 = interleukin-5; MCP-1 = monocyte chemoattractant protein-1; MIP-1β = macrophage inflammatory protein-1 beta; GM-CSF = granulocyte-macrophage colony stimulating-factor; MIP-1α = macrophage inflammatory protein-1 alpha; IL-17 = interleukin-17; IL-15 = interleukin-15; IL-13 = interleukin-13; RANTES = Regulated on Activation, Normal T Cell Expressed and Secreted; IL-12 = interleukin-12; IL-6 = interleukin-6; IFN-α = interferon alpha; IL-10 = interleukin-10; IL-1β = interleukin-1 beta