Clinical characteristics and associated factors of pediatric acute disseminated encephalomyelitis patients with MOG antibodies: a retrospective study in Hangzhou, China

Table 2 The MRI features of MOG-IgG-positive ADEM patients compared to MOG-IgG-negative ADEM patients

MRI lesions, n (%)	MOG-IgG-positive n = 35	MOG-IgG-negative n = 50	p value
Brain lesions
Frontal lobe	29 (82.8)*	34 (68)	0.019
Parietal lobe	19 (54.3)	27 (54)	0.140
Temporal lobe	18 (51.4)	23 (46)	1.000
Occipital lobe	13 (37.1)	14 (28)	0.664
Basal ganglia	17 (48.6)	22 (44)	0.825
Thalamus	16 (45.7)	14 (28)	0.380
Brainstem	13 (37.1)	14 (28)	0.478
Cerebellum	9 (25.7)	12 (24)	0.527
Corpus callosum	4 (14.3)	5 (10)	0.734
Optic nerve	6 (17.1)	4 (8)	0.305
Spinal cord lesions	15 (42.9)	29 (58)	0.662
LETM	6 (17.1)	9 (18)	0.580
Infratentorial lesions	16 (45.7)	19 (38)	0.380
Bilateral lesions	35 (100)	50 (100)	1.000
Residual cranial lesions	23 (65.7)	29 (58)	0.506
Residual spinal cord lesions	4 (11.4)	5 (10)	1.000

ADEM acute disseminated encephalomyelitis, MOG myelin oligodendrocyte glycoprotein, MOG-IgG-positive ADEM patients with positive anti-MOG antibodies in serum, MOG-IgG-negative ADEM patients without positive anti-MOG antibodies in serum, MRI magnetic resonance imaging, LETM longitudinal extensive transverse myelitis; univariate analyses were confirmed by the t-test, chi-square or Mann-Whitney U-test.
*indicates MOG-IgG-positive group vs. MOG-IgG-negative group, p < 0.05.

ISSN: 1471-2377