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Table 5 Correlations between plasma and CSF NfL with the MRI findings in SLE patients

From: Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus

 

Plasma NfL

CSF NfL

n

r

p-value

n

r

p-value

White matter lesion volume a

65

0.14

0.26

29

0.21

0.29

Total white matter volume a

71

0.053

0.66

32

0.036

0.73

Total grey matter volume a

71

−0.092

0.45

32

−0.065

0.73

Subcortical grey matter volume a

71

−0.038

0.76

32

0.15

0.43

Cortex volume b

71

−0.004

0.97

32

−0.20

0.29

Corpus callosum volume a

71

−0.075

0.54

32

0.11

0.57

Thalamus volume a

71

−0.076

0.54

32

0.096

0.61

Hippocampus volume a

70

−0.057

0.65

32

0.10

0.59

Pallidum volume a

71

0.004

0.97

32

0.053

0.78

Putamen volume a

71

0.055

0.65

32

0.089

0.64

Caudate volume a

71

0.14

0.26

32

0.30

0.11

Amygdala volume a

70

−0.232

0.057

32

−0.16

0.40

Accumbens volume a

71

−0.22

0.064

32

−0.016

0.93

CSF volume a

71

0.34

0.005

32

0.16

0.40

  1. r: Pearson’s correlation coefficient (log-NfL values used in the calculations). r: Pearson’s partial correlation coefficient adjusted for aage and total intracranial volume or bage
  2. CSF Cerebrospinal fluid, NfL Neurofilament Light