Plasma and cerebrospinal fluid neurofilament light concentrations reflect neuronal damage in systemic lupus Erythematosus

Table 6 Associations between plasma NfL and CNS-VS test results

BRIEF-CORE Clinical Domain	Valid tests	r	p-value	Domain impairment^a, n (%)
Multiple Test Domains
Neurocognitive Index	67	− 0.026	0.83	5 (8%)
Composite Memory	70	− 0.042	0.73	9 (13%)
Complex Attention	67	−0.044^b	0.72	8 (12%)
Cognitive Flexibility	68	0.019	0.88	8 (12%)
Single Test Domains
Psychomotor Speed	70	−0.19	0.11	4 (6%)
Reaction Time	69	−0.077	0.53	16 (23%)
Visual Memory	70	−0.002	0.99	9 (13%)
Processing Speed	70	−0.065	0.60	5 (7%)
Executive Function	69	−0.016	0.90	8 (12%)
Simple Attention	38	−0.41^b	0.010	4 (11%)
Motor Speed	39	−0.17	0.30	2 (5%)
Verbal Memory	70	−0.073	0.55	8 (11%)

r Pearson’s correlation coefficient, NfL Neurofilament Light, n Number of subjects, % Proportion of subjects, CNS-VS CNS-Vital Signs
^a“Domain impairment” defined by an individual score below minus 2 standard deviations
^bSpearman’s correlation coefficient

ISSN: 1471-2377