Table 1 baseline comparison between NLR Q1-Q4 groups

Age, years (median [IQR])

37 [33, 42]

37 [32, 41]

37 [33, 41]

38 [33, 42]

38 [34, 42]

0.07

Male, n (%)

580 (83.94)

148 (86.05)

153 (87.93)

140 (81.40)

138 (80.23)

0.16

Admission NIHSS score, (median [IQR])

2 [0, 5]

1 [0, 3]

1 [0, 4]

2 [1, 5]

3.5 [1, 7]

< 0.001

Thrombolysis, n (%)

31 (4.49)

2 (1.16)

7 (4.02)

7 (4.07)

15 (8.72)

0.01

Hypertension, n (%)

324 (46.89)

66 (38.37)

82 (47.13)

90 (52.33)

85 (49.42)

0.06

Diabetes, n (%)

120 (17.37)

28 (16.28)

32 (18.39)

35 (20.35)

24 (13.95)

0.45

Dyslipidemia, n (%)

91 (13.17)

25 (14.53)

23 (13.22)

19 (11.05)

24 (13.95)

0.79

Atrial fibrillation, n (%)

11 (1.59)

3 (1.74)

1 (0.57)

4 (2.33)

3 (1.74)

0.62

Prior ischemic stroke, n (%)

74 (10.71)

15 (8.72)

16 (9.20)

28 (16.28)

15 (8.72)

0.06

Prior hemorrhagic stroke, n (%)

9 (1.30)

3 (1.75)

2 (1.15)

1 (0.58)

2 (1.16)

0.79

Coronary heart disease, n (%)

22 (3.18)

4 (2.33)

6 (3.45)

6 (3.49)

6 (3.49)

0.91

Smoking status, n (%)

0.75

  Never smoker

302 (43.70)

69 (40.12)

75 (43.10)

80 (46.51)

77 (44.77)

  Past smoker

22 (3.18)

8 (4.65)

4 (2.30)

6 (3.49)

4 (2.33)

  Current smoker

367 (53.11)

95 (55.23)

95 (54.60)

86 (50.00)

91 (52.91)

Alcoholic status, n (%)

0.09

  Never drinked

475 (68.74)

103 (59.88)

128 (73.56)

123 (71.51)

120 (69.77)

  Past drinked

11 (1.59)

5 (2.91)

2 (1.15)

3 (1.74)

1 (0.58)

  Current drinking

205 (29.67)

64 (37.21)

44 (25.29)

46 (26.74)

51 (29.65)

Prior antiplatelet agents, n (%)

52 (7.53)

8 (4.65)

15 (8.62)

15 (8.72)

14 (8.14)

0.43

Prior anticoagulation agents, n (%)

11 (1.59)

2 (1.16)

1 (0.57)

4 (2.33)

4 (2.33)

0.47

Systolic blood pressure, mmHg (median [IQR])

141.00 [129.00, 161.00]

134.50 [124.00, 149.00]

145.00 [131.25, 160.00]

143.00 [132.00, 164.00]

148.00 [132.75, 170.00]

< 0.001

Diastolic blood pressure, mmHg (median [IQR])

91.00 [81.00, 104.00]

86.50 [78.00, 96.25]

91.50 [80.25, 104.00]

94.00 [84.75, 105.00]

94.50 [82.00, 110.00]

< 0.001

Triglyceride, mmol/L (median [IQR])

1.42 [1.03, 2.04]

1.46 [1.14, 2.15]

1.40 [1.03, 2.05]

1.52 [1.06, 2.20]

1.33 [0.99, 1.79]

0.1

Cholesterol, mmol/L (median [IQR])

3.74 [3.03, 4.53]

3.74 [3.12, 4.48]

3.60 [3.02, 4.43]

3.87 [3.08, 4.56]

3.83 [3.12, 4.64]

0.55

High density lipoprotein, mmol/L (median [IQR])

0.99 [0.85, 1.16]

1.03 [0.86, 1.17]

0.95 [0.82, 1.12]

0.98 [0.85, 1.13]

1.03 [0.86, 1.19]

0.06

Low density lipoprotein, mmol/L (median [IQR])

2.18 [1.63, 2.90]

2.18 [1.63, 2.87]

2.13 [1.62, 2.79]

2.25 [1.54, 3.01]

2.22 [1.71, 3.10]

0.62

CRP, mg/L (median [IQR])

1.18 [0.49, 3.66]

0.84 [0.33, 2.07]

1.01 [0.44, 2.77]

1.12 [0.52, 3.48]

2.57 [0.82, 9.48]

< 0.001

NLR (median [IQR])

2.60 [1.91, 3.85]

1.54 [1.25, 1.71]

2.21 [2.07, 2.39]

3.18 [2.89, 3.46]

5.51 [4.40, 7.82]

< 0.001

Glucose, mmol/L (median [IQR])

5.50 [4.70, 6.90]

5.00 [4.48, 6.10]

5.50 [4.57, 6.80]

5.65 [4.85, 7.04]

6.08 [5.20, 7.39]

< 0.001

Pulmonary infection, n (%)

32 (4.63)

1 (0.58)

3 (1.72)

9 (5.23)

19 (11.05)

< 0.001

Urinary infection, n(%)

5 (0.72)

0 (0.00)

0 (0.00)

3 (1.74)

2 (1.16)

0.14

Infectious diarrhea, n (%)

5 (0.72)

0 (0.00)

1 (0.57)

2 (1.16)

2 (1.16)

0.53

Deep venous thrombosis, n (%)

20 (2.89)

4 (2.33)

5 (2.87)

3 (1.74)

8 (4.65)

0.41

Hemorrhagic transformation, n (%)

101 (14.62)

20 (11.63)

22 (12.64)

26 (15.12)

33 (19.19)

0.20

TOAST, n (%)

0.09

  LAA

314 (45.44)

76 (44.19)

76 (43.68)

86 (50.00)

76 (44.19)

  CE

46 (6.66)

10 (5.81)

5 (2.87)

16 (9.30)

15 (8.72)

  SAA

80 (11.58)

21 (12.21)

24 (13.79)

15 (8.72)

19 (11.05)

  Other

150 (21.71)

37 (21.51)

36 (20.69)

31 (18.02)

46 (26.74)

  Unknown

101 (14.62)

28 (16.28)

33 (18.97)

24 (13.95)

16 (9.30)

mRS score at 90 days (median [IQR])

0.00 [0.00, 1.00]

0.00 [0.00, 1.00]

0.00 [0.00, 1.00]

1.00 [0.00, 1.25]

1.00 [0.00, 2.00]

< 0.001

mRS 0–1, n (%)

537 (77.71)

149 (86.63)

149 (85.63)

129 (75.00)

109 (63.37)

< 0.001