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Table 1 Comparison of baseline characteristics, procedure-related factors, in-stent restenosis and stroke between VBS and CAS

From: In-stent restenosis and stented-territory infarction after carotid and vertebrobasilar artery stenting

Variable

VBS

(N = 93)

CAS

(N = 324)

P-value

Age, years

63.0 ± 11.8

67.8 ± 9.3

< 0.001*

Male sex

74 (79.6)

267 (82.4)

0.637

Vascular risk factor

 Hypertension

68 (73.1)

229 (70.7)

0.743

 Diabetes

31 (33.3)

130 (40.1)

0.287

 Hyperlipidemia

45 (48.4)

157 (48.5)

> 0.999

 Coronary artery disease

16 (17.2)

102 (31.5)

0.010*

 Stroke history

36 (38.7)

105 (32.4)

0.313

Laboratory finding

 HbA1c, %

6.3 ± 0.9

6.3 ± 1.1

0.843

 LDL, mg/dL

89.1 ± 42.8

86.0 ± 34.3

0.529

 ARU ≥550

23 (26.4)

60 (19.4)

0.198

 PRU ≥275

10 (11.6)

33 (10.5)

0.927

 %PI < 20%

44 (51.2)

166 (53.0)

0.852

Procedure-related factors

 Lesion location

  

< 0.001*

  Intracranial

54 (58.1)

28 (8.6)

 

  Extracranial

39 (41.9)

296 (91.4)

 

 Symptomatic stenosis

85 (91.4)

246 (75.9)

0.002*

 Number of stents ≥2

1 (1.1)

9 (2.8)

0.574

 Maximum diameter of stents, mm

4.8 ± 1.8

7.1 ± 1.9

< 0.001*

 Total length of stents, mm

25.6 ± 9.6

34.6 ± 10.2

< 0.001*

 Pre-ballooning dilatation

79 (84.9)

278 (85.8)

0.968

 Post-ballooning dilatation

24 (25.8)

150 (46.3)

0.001*

 Maximum balloon pressure, atm

9.5 ± 3.6

10.7 ± 3.1

0.002*

Clinical outcome

 In-stent restenosis

12 (12.9)

22 (6.8)

0.092

 Follow-up period, months

20.0 [8.0–36.0]

16.0 [7.0–35.5]

0.203

 Any territory infarction

23 (24.7)

43 (13.3)

0.012*

 Follow-up period, months

31.0 [11.0–36.0]

24.0 [11.5–36.0]

0.427

 Stented-territory infarction

21 (22.6)

35 (10.8)

0.006*

 Follow-up period, months

33.0 [11.0–36.0]

24.0 [12.0–36.0]

0.423

 Periprocedural (≤1 month)

6 (6.5)

24 (7.4)

0.931

 Long-term (> 1 month)

15 (16.1)

11 (3.4)

< 0.001*

  1. Values are expressed as number (%), mean ± standard deviation, and median [interquartile range]
  2. CAS Carotid artery stenting, VBS Vertebrobasilar artery stenting, HbA1c Hemoglobin A1c, LDL Low-density lipoprotein, ARU Aspirin reaction unit, PRU P2Y12 reaction unit, %PI Percent platelet inhibition, TIA Transient ischemic attack
  3. * Statistically significant (P < 0.05)