Fig. 1

Development of individual CHOP Intend scores of SMA patients and pre-symptomatic individuals following OA treatment. Gray arrows indicate administration of OA in two SMA type 1 patients with nusinersen pretreatment. In all other patients the first assessment was done within 1-7 days prior to OA treatment. Asterix indicates a CHOP Intend score that was not included into the analysis, because the patient was suffering from an acute respiratory infection at the time of the assessment