Table 2 Comparison of clinical characteristics between the lower and the higher homocysteine level group
Variables | Homocysteine level (μmol/L) | P value | |
|---|---|---|---|
Lower group (<15.5 umol/L, n=285) | Higher group (≥15.5 umol/L, n=142) | ||
Sex, male | 153(53.7) | 103(72.5) | <0.001 |
Age, years | 65.51±13.47 | 71.05±13.90 | <0.001 |
Systolic BP on admission, mmHg | 147.21±23.92 | 148.70±24.04 | 0.733 |
Diastolic BP on admission, mmHg | 85.31±14.50 | 85.78±15.85 | 0.545 |
NIHSS on admission | 5.0(2.5-12.0) | 8.0(3.0-14.0) | 0.018 |
Vascular risk factors | |||
Hypertension | 148(51.9) | 99(69.7) | <0.001 |
Diabetes mellitus | 49(17.2) | 39(27.5) | 0.013 |
Hyperlipidemia | 14(4.9) | 3(2.1) | 0.163 |
Atrial fibrillation | 42(14.7) | 32(22.5) | 0.045 |
Current smoking | 105(36.8) | 55(38.7) | 0.704 |
Alcohol consumption | 64(22.5) | 39(27.5) | 0.254 |
Previous history of cardiovascular events | |||
Myocardial infarction | 5(1.8) | 6(4.2) | 0.193 |
Transient ischemic attack | 3(1.1) | 6(4.2) | 0.066 |
Previous ischemic stroke | 43(15.1) | 28(19.7) | 0.226 |
Previous hemorrhagic stroke | 2(0.7) | 4(2.8) | 0.098 |
TOAST classification of stroke etiology | 0.820 | ||
Large-artery atherosclerosis | 87(30.5) | 41(28.9) | |
Small-vessel occlusion | 72(25.3) | 32(22.5) | |
Cardioembolism | 73(25.6) | 43(30.3) | |
Other cause | 9(3.2) | 3(2.1) | |
Undetermined etiology Stroke | 44(15.4) | 23(16.2) | |
Glucose on admission, mmol/L | 8.06±3.53 | 7.78±2.98 | 0.425 |
Blood creatine on admission, μmol/L | 71.86±18.18 | 97.34±65.77 | <0.001 |
Therapies after stroke onset | |||
Thrombolysis | 31(10.9) | 13(9.2) | 0.581 |
Thrombectomy | 12(4.2) | 8(5.6) | 0.517 |
Anticoagulation | 41(14.4) | 20(14.1) | 0.933 |
Antiplatelet | 276(96.8) | 129(90.8) | 0.008 |
Statin | 269(95.7) | 131(92.3) | 0.137 |
Interval time from stroke onset to admission, h | 7.0(4.0-24.0) | 6.0(3.0-24.0) | 0.568 |
Interval time from admission to blood sampling, h | 18.1(13.0-21.1) | 18.3(14.1-21.4) | 0.771 |
HT | 29(10.2) | 27(19.0) | 0.011 |
PH | 11(3.9) | 17(12.0) | 0.001 |