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Table 1 Baseline characteristics according to CONUT scoring system

From: The association between malnutrition status and hemorrhagic transformation in patients with acute ischemic stroke receiving intravenous thrombolysis

 

Normal

(CONUT 0–1)

(n = 488)

Mild

(CONUT 2–4)

(n = 276)

Moderate to severe

(CONUT 5–12)

(n = 44)

p-value

Age (SD)

65.2 (12.7)

68.6 (13.8)

71.3 (13.8)

< 0.001

Male, n (%)

311 (63.7)

178 (64.5)

24 (54.5)

0.44

NIHSS (IQR)

7 (5–11)

8 (5–14)

8 (6–13)

0.02

BMI, kg/m2 (SD)

24.0 (22.0-25.7)

23.7 (21.2–25.6)

22.3 (20.8–24.6)

0.01

Stroke mechanism, n (%)

   

0.04

SVO

89 (18.2)

29 (10.5)

3 (6.8)

 

LAA

146 (29.9)

81 (29.3)

14 (31.8)

 

CE

132 (27.0)

95 (34.4)

126 (36.4)

 

UD

106 (21.7)

63 (22.8)

11 (25.0)

 

OD

15 (3.1)

8 (2.9)

0 (0.0)

 

Interval from arrival to IVT, min (IQR)

39 (28–54)

40 (31–55)

44 (36-55.5)

0.22

Previous stroke, n (%)

73 (15.0)

52 (18.8)

14 (31.8)

0.01

HTN, n (%)

292 (59.8)

163 (59.1)

25 (56.8)

0.92

DM, n (%)

112 (23.0)

101 (36.6)

15 (34.1)

< 0.001

HL, n (%)

92 (18.9)

53 (19.2)

10 (22.7)

0.83

CAD, n (%)

28 (5.3)

44 (15.9)

5 (11.4)

< 0.001

Current smoking, n (%)

113 (23.2)

52 (18.8)

8 (18.2)

0.33

Atrial fibrillation, n (%)

132 (27.0)

94 (34.1)

18 (40.9)

0.04

Previous use of antithrombotics, n (%)

116 (23.8)

93 (33.7)

11 (25.0)

0.01

tPA dose, n (%)

   

0.002

0.6 mg/kg

73 (15.0)

17 (6.2)

4 (9.1)

 

0.9 mg/kg

415 (85.0)

259 (93.8)

40 (90.9)

 

Total cholesterol, mg/dL (SD)

190.8 (35.5)

134.9 (28.5)

112.3 (14.4)

< 0.001

Albumin, mg/dL (SD)

4.2 (0.4)

4.1 (0.4)

2.8 (0.8)

< 0.001

Hemoglobin, g/dL (SD)

13.9 (2.0)

13.5 (1.9)

13.2 (2.1)

0.001

Creatinine, mg/dL (SD)

0.93 (0.32)

1.11 (0.79)

1.10 (0.49)

< 0.001

Platelet, x1000/µL (SD)

235.7 (68.9)

215.9 (70.6)

221.1 (77.0)

0.001

LDL, mg/dL (SD)

118.1 (30.2)

85.4 (29.8)

97.8 (41.8)

< 0.001

HbA1c, % (SD)

6.1(1.2)

6.1 (1.0)

6.0 (1.2)

0.37

Prothrombin time, INR (SD)

1.01 (0.11)

1.04 (0.14)

1.04 (0.17)

0.01

CRP, mg/dL (SD)

6.8 (14.1)

8.3 (15.6)

12.8 (39.7)

0.054

Initial random glucose, mg/dL (SD)

142.4 (53.0)

147.9 (64.1)

136.6 (61.5)

0.30

SBP, mmHg (SD)

155.1 (28.1)

148.6 (25.5)

156.4 (25.5)

0.01

PNI, (IQR)

54.6 (50.6–59.5)

48.8 (42.2–54.0)

31.6 (29.9–37.4)

< 0.001

  1. Abbreviation: CONUT, controlling nutritional status; SD, standard deviation; NIHSS, National Institute Health of Stroke Scale; BMI, body mass index; IQR, interquartile range; SVO, small vessel occlusion; LAA, large artery atherosclerosis; CE, cardioembolism; UD, undetermined; OD, other determined; IVT, intravenous thrombolysis; HTN, hypertension; DM, diabetes mellitus; HL, hyperlipidemia; CAD, coronary artery disease; tPA, tissue plasminogen activator; LDL, low density lipoprotein; HbA1c, glycated hemoglobin; INR, international normalized ratio; CRP, C reactive protein; SBP, systolic blood pressure; PNI, prognostic nutritional index
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BMC Neurology

ISSN: 1471-2377

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