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Table 3 Multivariate analysis showing association between CONUT scoring system and outcomes

From: The association between malnutrition status and hemorrhagic transformation in patients with acute ischemic stroke receiving intravenous thrombolysis

 

END-SHT

 

Any HT

 

END-prog

 

3-month mRS 3–6

 
 

OR

95% CI

p-value

OR

95% CI

p-value

OR

95% CI

p-value

OR

95% CI

p-value

CONUT scoring system

normal

ref

ref

ref

ref

mild

0.57

0.20–1.62

0.30

0.85

0.43–1.68

0.64

0.34

0.12–1.03

0.057

1.27

0.78–2.05

0.34

moderate to severe

12.23

2.41–62.07

0.003

7.90

2.20–28.40

0.002

3.01

1.51–17.79

0.03

3.10

1.12–8.55

0.03

Age

1.02

0.98–1.05

0.34

1.01

0.99–1.03

0.43

1.03

0.99–1.06

0.19

1.05

1.03–1.07

< 0.001

Male

0.87

0.39–1.98

0.75

1.22

0.69–2.17

0.49

1.28

0.57–2.84

0.55

0.77

0.51–1.12

0.16

NIHSS

1.02

0.95–1.09

0.66

1.01

0.97–1.06

0.57

1.05

0.99–1.12

0.08

1.16

1.12–1.20

< 0.001

Stroke mechanism

SVO

ref

ref

ref

ref

LAA

0.98

0.26–3.64

0.98

1.17

0.46–2.99

0.74

1.74

0.53–5.79

0.36

1.67

0.94–2.99

0.08

CE

0.70

0.14–3.57

0.67

1.83

0.58–5.75

0.3

1.19

0.18–8.14

0.86

0.95

0.40–2.23

0.91

UD

0.98

0.25–3.89

0.97

1.55

0.60–4.02

0.37

0.35

0.07–1.87

0.22

1.13

0.60–2.13

0.70

OD

1.27

0.11–14.26

0.85

0.79

0.09–7.05

0.83

1.12

0.14–16.24

0.68

1.84

0.62–5.45

0.27

Previous stroke

0.68

0.24–1.96

0.48

0.98

0.50–1.91

0.94

0.37

0.11–1.24

0.11

1.45

0.89–2.38

0.14

DM

0.41

0.16–1.05

0.06

0.79

0.45–1.39

0.41

2.43

1.17–5.03

0.02

1.67

1313 − 2.48

0.01

CAD

1.79

0.54–5.91

0.34

1.47

0.60–3.57

0.40

0.67

0.13–3.51

0.63

1.6

0.83–3.06

0.16

Atrial fibrillation

2.04

0.57–7.28

0.27

1.01

0.54–1.87

0.98

1.55

0.31–7.71

0.60

1.53

0.75–3.11

0.24

Previous use of antithrombotics

1.22

0.49–3.06

0.67

1.01

0.54–1.87

0.98

0.62

0.24–1.58

0.31

0.46

0.29–0.74

0.001

tPA dose,

1.36

0.37–4.98

0.65

3.30

1.06–10.26

0.04

2.10

0.36–5.75

0.48-

0.95

0.55–1.64

0.84

Total cholesterol

0.98

0.96–0.996

0.01

0.98

0.97–0.99

< 0.001

1.00

0.99–1.02

0.70

1.00

0.99–1.01

0.91

Albumin

0.46

0.19–1.11

0.08

0.90

0.49–1.65

0.73

1.57

0.66–3.73

0.31

1.12

0.73–1.73

0.6

Hemoglobin

1.23

0.98–1.55

0.08

1.18

1.01–1.39

0.04

0.82

0.66–1.02

0.07

1.04

0.94–1.16

0.44

Platelet

1.00

0.995–1.01

0.92

1.00

0.996-1.00

0.80

1.00

0.995–1.01

0.98

1.00

0.998-1.00

0.86

Creatinine

1.37

0.73–2.58

0.33

1.04

0.65–1.66

0.89

0.73

0.30–1.80

0.49

1.61

1.12–2.31

0.01

LDL

1.02

1.01–1.04

0.01

1.02

1.01–1.04

< 0.001

1.00

0.98–1.02

0.97

1.01

0.998–1.02

0.14

PT

3.54

0.49–25.12

0.21

0.98

0016-6.06

0.98

1.22

0.10-15.32

0.88

0.75

0.19–2.87

0.67

CRP

1.01

0.996–1.03

0.15

1.01

1.00-1.03

0.045

1.00

0.99–1.02

0.66

1.01

0.998–1.02

0.11

  1. Abbreviation: CONUT, controlling nutritional status; END-SHT, symptomatic hemorrhagic transformation; HT, hemorrhagic transformation; END-prog; stroke progression; mRS, modified Rankin Scale; OR, odds ratio; CI, confidence interval; NIHSS, National Institute Health of Stroke Scale; SVO, small vessel occlusion; LAA, large artery atherosclerosis; CE, cardioembolism; UD, undetermined; OD, other determined; DM, diabetes mellitus; HL, hyperlipidemia; CAD, coronary artery disease; tPA, tissue plasminogen activator; LDL, low density lipoprotein; PT, prothrombin time; CRP, C-reactive protein
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BMC Neurology

ISSN: 1471-2377

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