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Table 3 Association of BMI/WHtR with outcomes

From: Association of body mass index and waist-to-height ratio with outcomes in ischemic stroke: results from the Third China National Stroke Registry

 

Number at risk

Number of events, N (%)

Unadjusted Hazard Ratio(95%CIa

P-value

Adjusted Hazard Ratio(95%CI) b

P-value

Pinteraction with stroke subtypec

mortality

BMI groups, kg/m2

      

0.6751

 < 18.5

309

32 (10.36%)

2.55 (1.75–3.73)

 < 0.0001

1.70 (1.16–2.49)

0.007

 

18.5- < 23

3855

162 (4.20%)

1.00 (Ref)

 

1.00 (Ref)

  

23- < 27.5

7491

235 (3.14%)

0.74 (0.61–0.91)

0.0035

0.94 (0.77–1.16)

0.5779

 

 ≥ 27.5

2491

57 (2.29%)

0.54 (0.40–0.73)

 < 0.0001

0.76 (0.56–1.03)

0.0784

 

WHtR groups

      

0.6714

 ≥ 0.57

1130

35 (3.10%)

0.64 (0.43–0.97)

0.0357

0.70 (0.46–1.07)

0.0977

 

0.52- < 0.57

1190

25 (2.10%)

0.43 (0.27–0.68)

0.0004

0.42 (0.26–0.67)

0.0003

 

0.47- < 0.52

1316

63 (4.79%)

1.00 (Ref)

 

1.00 (Ref)

  

 < 0.47

1169

67 (5.73%)

1.21 (0.86–1.71)

0.2785

0.91 (0.64–1.29)

0.5937

 

Recurrence of stroke

BMI groups, kg/m2

      

0.6263

 < 18.5

309

36 (11.65%)

1.22 (0.87–1.72)

0.2525

1.13 (0.80–1.59)

0.5005

 

18.5- < 23

3855

382 (9.91%)

1.00 (Ref)

 

1.00 (Ref)

  

23- < 27.5

7491

741 (9.89%)

1.00 (0.88–1.13)

0.9329

1.03 (0.91–1.17)

0.6484

 

 ≥ 27.5

2491

265 (10.64%)

1.07 (0.92–1.26)

0.3709

1.13 (0.96–1.32)

0.1499

 

WHtR groups

      

0.9101

 ≥ 0.57

1130

132 (11.68%)

1.07 (0.84–1.35)

0.6012

1.10 (0.87–1.40)

0.4345

 

0.52- < 0.57

1190

101 (8.49%)

0.76 (0.59–0.98)

0.032

0.77 (0.60–0.99)

0.0440

 

0.47- < 0.52

1316

145 (11.02%)

1.00 (Ref)

 

1.00 (Ref)

  

 < 0.47

1169

111 (9.50%)

0.86 (0.67–1.10)

0.2339

0.83 (0.65–1.07)

0.1440

 

Combined vascular event

BMI groups, kg/m2

      

0.6467

 < 18.5

309

39 (12.62%)

1.24 (0.90–1.73)

0.1934

1.14 (0.82–1.58)

0.4469

 

18.5- < 23

3855

307 (10.56%)

1.00 (Ref)

 

1.00 (Ref)

  

23- < 27.5

7491

784 (10.47%)

0.99 (0.88–1.11)

0.8354

1.02 (0.91–1.15)

0.7288

 

 ≥ 27.5

2491

275 (11.04%)

1.05 (0.90–1.22)

0.5664

1.10 (0.94–1.28)

0.2474

 

WHtR groups

      

0.8802

 ≥ 0.57

1130

140 (12.39%)

1.04 (0.83–1.30)

0.7576

1.07 (0.85–1.35)

0.5679

 

0.52- < 0.57

1190

107 (8.99%)

0.74 (0.58–0.94)

0.0194

0.75 (0.58–0.95)

0.0198

 

0.47- < 0.52

1316

158 (12.01%)

1.00 (Ref)

 

1.00 (Ref)

  

 < 0.47

1169

115 (9.84%)

0.82 (0.64–1.04)

0.1005

0.79 (0.62–1.00)

0.0511

 
  1. awere calculated using univariate COX proportional hazard models; bwere calculated using multivariable COX proportional hazard models adjusted for age, gender, ethnicity, history of diabetes mellitus, history of atrial fibrillation, history of hypertension, history of myocardial infarction, history of lipid metabolism disorders, heavy drinking, smoking, intravenous thrombolysis, arterial thrombolysis or mechanical thrombectomy, NIHSS at admission, TOAST subtypes. cPinteraction with stroke subtype, the interactions of BMI/WHtR with stroke subtype were investigated with the addition of BMI/WHtR by stroke subtype groups using multivariable Cox proportional hazards models. BMI body mass index, WHtR waist-to-height ratio, TOAST Trial of Org 10,172 in Acute Stroke Treatment, NIHSS National Institutes of Health Stroke Scale