Fig. 1

Region of interest (ROI)-to-ROI connectome ring maps of all selected ROI seeds in Post vs. Pre nabiximols exposure (all patients). Increased connectivity (a). Decreased connectivity (b). The colour links are obtained at a ROI-to-ROI connections height threshold (FDR) of P < 0.05, seed ROI height threshold (uncorrected) of P < 0.05, with one-sided positive seed level correction and permutation tests. The colour bar indicates the statistical T value. Abbreviations: ROI (region of interest), FDR (false discovery rate), ICC l (Intracalcarine Cortex left), aMTG r (Middle Temporal Gyrus, anterior division Right), pSTG l (Superior Temporal Gyrus, posterior division Left), MidFG r (Middle Frontal Gyrus Right), Ver6 (Vermis 6), Cereb45 r (Cerebellum 4 5 Right), OP r (Occipital Pole Right), pTFusC r (Temporal Fusiform Cortex, posterior division Right), aTFusC r (Temporal Fusiform Cortex, anterior division Right), FO r (Frontal Operculum Cortex Right)