Fig. 5

Seed-to-Voxel statistically significant clusters maps using precentral and postcentral gyrus as a seed ROIs, according to responder status. Pre (a) and Post (b) condition in Sativex® non responders and Pre (c) and Post (d) condition in responders. Results are visualized as clusters on inflated brain (p < 0.05, FDR corrected). In post condition (b), there is an increase in connectivity in pre and post central gyrus compared to the pre-condition in non-responders. Same condition is evident in responders (c, d), despite in pre-condition (c) there are no significant clusters