Fig. 3

Pathological findings. Extensive hemosiderin deposition on the brain (A) and spinal cord (B). Marked atrophy of the spinal gray matter such as the anterior horns and intermediate zone at the C5 (C) and C8 (D) segments. Severe neuronal cell loss without apparent chromatolysis in both anterior horns and intermediate zone at the C5 segment (E). No obvious tissue damage in the posterior horns at the C5 segment (F). Relatively preserved spinal gray matter at the L4 segment (G). Persistence of many motor neurons in the anterior horn at L4 (H). A chromatolytic neuron in Fig. 3H (I). C, D, G Klüver-Barrera staining, E, F, H, I Hematoxylin and eosin staining. Scale bars in E, F, H are 100 μm. Scale bar in I is 50 μm