Fig. 2

Treatment response for patients diagnosed with EM or CM receiving the first (N = 171), second (N = 34) or third (N = 7) monoclonal antibody. Absolute numbers are given; percentages can be gathered from the y-axis. Response was defined as ≥ 50% reduction of monthly migraine days (MMDs) in episodic migraine and ≥ 30% reduction of MMDs in chronic migraine after an adequate treatment duration of at least 3 months. Vice versa, non-response was defined as ≤ 50% reduction of MMDs in EM and ≤ 30% reduction of MMDs in CM after 3 months of treatment. Loss of effectiveness was defined as an initial response, but with a subsequent increase in migraine frequency back to or beyond the baseline level. Side effects that led to a discontinuation or switch of the treatment were rare and included erythema, itching and swelling at the site of injection, muscle cramps as well as constipation. Other reasons for stopping/switching the treatment included for example reimbursement issues