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Fig. 1 | BMC Neurology

Fig. 1

From: Longitudinal prospective cohort study to assess peripheral motor function with extensive electrophysiological techniques in patients with Spinal Muscular Atrophy (SMA): the SMA Motor Map protocol

Fig. 1

Study protocol of the SMA Motor Map. Part one is performed in SMN2-splicing modifier treatment-naïve patients (baseline). If the participant starts treatment with either nusinersen or risdiplam and consents to participate longitudinally, the participant will be included in part two (additional measurement at two months and 10 to 14 months, depending on therapy). Participants can take part at part one without participation in part two. The study protocol includes electrophysiological assessments (compound muscle action potential (CMAP), CMAP scan, motor nerve excitability testing, repetitive nerve stimulation (RNS) and the sensory nerve action potential (SNAP)) at all visits. Functional motor assessments (Hammersmith Functional Motor Scale Expanded (HFMSE), Revised Upper Limb Module (RULM) and Adult Test of Neuromuscular Disorders (ATEND)) are performed at baseline and at the second follow-up measurement. The electrophysiological test set is performed in the same order at all visits

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BMC Neurology

ISSN: 1471-2377

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