Table 2 Comparison of major bleeding and death incidence between drug-exposed types

Unadjusted

N (total = 2,285)

Antiplatelet

Anticoagulation

Combination

Discontinuation

Intracranial hemorrhage

119 (5.21)

1

1.800 (1.433—2.259)

1.798 (0.928—3.484)

0.672 (0.584—0.774)

Gastrointestinal bleeding

671 (29.37)

1

1.196 (1.062—1.345)

1.755 (1.293—2.383)

0.684 (0.642—0.728)

Major bleeding

774 (33.87)

1

1.326 (1.189—1.480)

1.639 (1.207—2.225)

0.707 (0.665—0.750)

Death

1,531 (67.00)

1

1.127 (1.056—1.204)

1.912 (1.640—2.229)

1.155 (1.117—1.194)

Model 1^a

N (total = 2,285)

Antiplatelet

Anticoagulation

Combination

Discontinuation

Intracranial hemorrhage

119 (5.21)

1

1.826 (1.453—2.294)

1.943 (1.002—3.767)

0.689 (0.598—0.792)

Gastrointestinal bleeding

671 (29.37)

1

1.214 (1.078—1.366)

1.710 (1.259—2.321)

0.689 (0.647—0.733)

Major bleeding

774 (33.87)

1

1.348 (1.208—1.504)

1.619 (1.192—2.198)

0.712 (0.671—0.756)

Death

1,531 (67.00)

1

1.140 (1.068—1.218)

1.771 (1.519—2.065)

1.181 (1.142—1.221)

Model 2^b

N (total = 2,285)

Antiplatelet

Anticoagulation

Combination

Discontinuation

Intracranial hemorrhage

119 (5.21)

1

1.427 (1.104—1.845)

1.569 (0.805—3.056)

0.659 (0.572—0.759)

Gastrointestinal bleeding

671 (29.37)

1

1.284 (1.129—1.460)

1.709 (1.256—2.325)

0.688 (0.646—0.732)

Major bleeding

774 (33.87)

1

1.350 (1.198—1.522)

1.537 (1.130—2.091)

0.706 (0.665—0.750)

Death

1,531 (67.00)

1

1.041 (0.968—1.119)

1.715 (1.469—2.002)

1.188 (1.149—1.229)