Sub-symptom threshold aerobic exercise for patients with persisting post-concussion symptoms and exercise intolerance after mild traumatic brain injury – a study protocol with a nested feasibility study for a randomized controlled trial

Table 1 Standard Protocol Items: Recommendation for interventional Trials (SPIRIT) of the current randomized controlled trial

		STUDY PERIOD
	Enrolment	Baseline test	Allocation	*Intervention*	Assessments
TIMEPOINT		T₀			T₁ *(12 weeks)*	T₂ *(6 months)*
ENROLMENT:
Eligibility screen	X
Informed consent	X
Allocation			X
INTERVENTIONS:
*SSTAE group*				X
*TAU group*				X
ASSESSMENTS:
Primary outcome measures: *Post-concussion symptoms – RPQ*		X			X	X
*Secondary outcome measure:* Exercise intolerance – BCTT		X			X	X
*Other outcomes*		X			X	X

Abbreviation: SSTAE Sub-symptom threshold aerobic exercise, TAU Treatment as usual, RPQ Rivermead Post-concussion symptoms questionnaire, BCTT Buffalo Concussion Treadmill Test

ISSN: 1471-2377