Sub-symptom threshold aerobic exercise for patients with persisting post-concussion symptoms and exercise intolerance after mild traumatic brain injury – a study protocol with a nested feasibility study for a randomized controlled trial

Table 3 Outcome measures

Outcome	Outcome Measure	Feasibility study	RCT
Primary outcome
Symptom burden	Rivermead Post-concussion Symptoms Questionnaire (RPQ) [36, 37]	x	x
Secondary outcome
Exercise intolerance	Buffalo Concussion Treadmill Test (BCTT) [22, 23]	x	x
Other outcomes
Headache symptoms and severity	Headache Impact Test (HIT-6) [38]	x	x
Fatigue	Fatigue Severity Scale (FSS)) [39]	x	x
Anxiety	Generalized Anxiety Disorder Scale (GAD-7) [40]	x	x
Depressive symptoms	Patient Health Questionnaire (PHQ-9) [41, 42]	x	x
Estimates of physical activity	International physical activity questionnaire (IPAQ) [43]	x	x
Health-related quality of life	Quality of Life after Brain Injury (QOLIBRI) [44]	x
Health-related quality of life	Quality of Life after Brain Injury Overall Scale (QOLIBRI-OS) [45]		x
Adherence to the intervention	The Problematic Experience of Therapy scale (PETS) [46]		x
Dizziness	Dizziness Handicap Inventory (DHI) [47]	x
Activity limitations	Patient-specific functional scale (PSFS) [48, 49]	x	x

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