Table 1 Univariate and multivariate survival analysis results of various factors in the training group and validation group

TARDBP

1.005(1.001-1.008)

0.009

1.006(1.001-1.011)

0.019

PRS type

2.182(1.785-2.667)

<0.001

2.515(1.956-3.234)

<0.001

Age

1.026(1.018-1.035)

<0.001

1.013(1.004-1.023)

0.006

IDH mutation

0.323(0.262-0.399)

<0.001

0.588(0.431-0.804)

<0.001

1p/19q codeletion

0.268(0.193-0.372)

<0.001

0.447(0.295-0.678)

<0.001

Grade

2.545(1.846-3.508)

<0.001

2.247(1.489-3.391)

<0.001

Grade*

6.968(5.081-9.554)

<0.001

3.814(2.451-5.937)

<0.001

Radiation therapy

1.241(0.953-1.615)

0.109

-

-

TMZ treatment

1.242(0.974-1.586)

0.081

-

-

MGMT methylation

0.795(0.639-0.990)

0.041

0.918(0.72-1.17)

0.489

Gender

1.061(0.868-1.296)

0.564

-

-

TARDBP

1.028(1.021-1.034)

<0.001

1.017(1.009-1.025)

<0.001

PRS type

2.874(2.160-3.824)

<0.001

3.095(2.177-4.400)

<0.001

Age

1.033(1.020-1.046)

<0.001

1.015(1.001-1.029)

0.030

IDH mutation

0.355(0.269-0.468)

<0.001

0.645(0.447-0.929)

0.018

1p/19q codeletion

0.170(0.104-0.277)

<0.001

0.349(0.201-0.605)

<0.001

Grade

3.497(2.287-5.348)

<0.001

2.900(1.806-4.655)

<0.001

Grade*

8.896(5.992-13.206)

<0.001

5.144(3.152-8.396)

<0.001

Radiation therapy

0.632(0.457-0.872)

0.005

0.945(0.649-1.376)

0.768

TMZ treatment

1.445(1.078-1.937)

0.014

0.508(0.360-0.718)

<0.001

MGMT methylation

0.830(0.632-1.089)

0.178

-

-

Gender

0.941(0.716-1.236)

0.660

-

-