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Table 2 Current status of pseudorabies virus infection in human

From: A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing

Case

Reference

Encephalitis

Endophthalmitis

Cerebrospinal fluid (mNGS)

Intraocular fluid(mNGS)

Treatment

Other organs

Y/N

Outcome

Y/N

Optic examination

Pupil dilation

Light reflex

Outcome

Neg/Pos

Onset to sampling (D)

Neg/Pos

Onset to sampling(D)

1

Zhou etal [17]

Y

Unconsciousness

N

ND

ND

ND

ND

Pos

14

ND

ND

ACV

1

2

Zhou etal. [17]

Y

Died

N

ND

ND

ND

NA

Pos

11

ND

ND

ACV + IVIG

1

3

Fan etal [9]

Y

Died

Y

Funduscopy

ND

ND

NA

Pos

7

ND

ND

ACV + IVIG + MPS

1 + 2

4

Fan etal [9]

Y

m RS 3

Y

Funduscopy

OCT

ND

ND

Improved

Pos

4

ND

ND

ACV + PFAt + MPS

1 + 2

5

Fan etal [9]

Y

m RS 3

N

ND

Dilation

Disappear

ND

Pos

2

ND

ND

ACV + IVIG

1 + 2

6

Fan etal [9]

Y

Died

Y

Funduscopy

ND

ND

NA

Pos

2190

ND

ND

ACV + Foscarnet

1 + 2

7

Fan etal [9]

Y

Died

Y

Funduscopy

Irregular

Slow

ND

Pos

2

ND

ND

ACV + IVIG + GC

1 + 2

8

Fan etal [9]

Y

died

N

N

Equal

Sensitive

ND

Pos

4

ND

ND

ACV + MPS

1 + 2

9

Fan etal [9]

Y

mRS 5

N

N

Equal

Sensitive

ND

Pos

4

ND

ND

ACV + IVIG + MPS

1 + 2

10

Liu etal [10]

Y

Improved

Y

Fundus images

OCT

ND

ND

Blindness

Pos

6

ND

ND

PFA

ND

11

Liu etal [10]

Y

Improved

N

ND

ND

ND

ND

Pos

7

ND

ND

PFA

1

12

Liu etal [10]

Y

Unconsciousness

Y

ND

ND

ND

ND

Pos

9

ND

ND

PFA

1

13

Yang etal [7]

Y

Unconsciousness

Y

ND

ND

ND

ND

Pos

8

ND

ND

RBV + MPS + IVIG

1 + 3

3

14

Wang etal [18]

Y

Improved

N

ND

ND

ND

ND

Pos

5

ND

ND

ACV + GC

1

15

Yang etal [11]

Y

mRS 4

N

ND

ND

ND

ND

Pos

5

ND

ND

IVIG + GC + Antiviral

2

16

Yang etal [11]

Y

Unconsciousness

N

ND

ND

ND

ND

Pos

9

ND

ND

IVIG + GC + Antiviral

2

17

Yang etal [11]

Y

mRS 3

Y

Funduscopy

ND

Disappear

Blurry vision/Recurrence

Pos

10

Pos

120

IVIG + GC + ACV

 + Eye surgery

2

18

Yang etal [11]

Y

Unconsciousness

N

ND

ND

ND

ND

Pos

5

ND

ND

IVIG + GC + antiviral

2

19

Yang etal [11]

Y

mRS 3

Y

Funduscopy

Ultrasound

ND

ND

Blindness/Recurrence

Pos

12

ND

ND

IVIG + GC + Antiviral

2 + 4

20

Hu etal [12]

Y

Improved

Y

Fundus images Ultrasound

ND

ND

Blindness/Recurrence

Pos

90

Pos

ND

ACV + Eye surgery

ND

21

Yan etal [13]

Y

Unconsciousness

Y

ND

3 mm

L-sluggishly R-disappear

ND

Pos

11

Pos

11

PFA + ACV + MPS

2

22

Ying etal [14]

Y

Improved

Y

OCT

FFA

ND

Sluggishly

Impaired vision

Pos

8

Pos

23

GCV + PFA

ND

23

Ai etal [6]

N

Improved

Y

Fundus images

OCT

ND

Sluggishly

Impaired vision

Neg

NA

Pos

16

Vitrectomy + VCV

ND

24

Liu etal [15]

Y

mRS 3

Y

Fundus images Ultrasound

Dilation

Disappear

Blindness

Pos

18

Pos

2

IVIG + GCV + MPS

ND

25

Liu etal [16]

Y

Improved

Y

Fundus images Ultrasound

ND

Sluggishly

Impaired vision

Pos

2/41/54

ND

ND

GCV + ACV + PFA + GC

ND

  1. L Left, R Right, mRS Modified Rankin Scale, ND No description, Neg Negative, Pos Positive
  2. Optic examination: FFA Fundus fluorescein angiography, OCT Optical coherence tomography
  3. Treatment: ACV Acyclovir, VCV valacyclovir, GCV ganciclovir, PFA Phosphine formic acid/Foscarnet; RBV Ribavirin, MPS Methylprednisolone, GC glucocorticoids, IVIG intravenous immunoglobulin
  4. Other organs: 1 = respiratory failure; 2 = Pneumonia;3 = gastrostomy tubes; 4 = peptic ulcer
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BMC Neurology

ISSN: 1471-2377

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