Fig. 3

Scatter plot with linear regression line between Wnt/β-catenin-related significantly expressed genes and between DKK3 expression and immune cell fractions in all grade II to IV gliomas. (A) Scatter plot with linear regression lines showing the association between DKK3 and CSNK1A1, FSTL1, and CTNNB1 gene expression based on the WHO grade of glioma; (B) Scatter plot with linear regression lines showing the association among CSNK1A1, FSTL1, and CTNNB1 gene expression based on the WHO grade of glioma; (C) (Left) Scatterplot with a linear regression line and LOWESS curve showing the overall relationship between DKK3 expression and the CD8 + T-cell fractions in all grade II to IV gliomas; (Right) Scatter plot with linear regression lines showing the associations between DKK3 expression and the CD8 + T-cell fractions according to WHO grade II or III glioma and GBM; (D) (Left) Scatterplot with a linear regression line and LOWESS curve showing the overall relationship between DKK3 expression and the memory B-cell fractions in all grade II to IV gliomas; (Right) Scatter plot with linear regression lines showing the associations between DKK3 expression and the memory B-cell fractions according to WHO grade II or III glioma and GBM.

CSNK1A1, casein kinase 1 alpha 1; CTNNB1, catenin beta 1; DKK3, dickkopf Wnt signaling pathway inhibitor 3; FSTL1, follistatin-like 1; GBM, glioblastoma multiforme